ID A0A2U2ZE18_9ACTN Unreviewed; 1454 AA.
AC A0A2U2ZE18;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=BREX system serine/threonine kinase PglW {ECO:0000313|EMBL:PWI10543.1};
GN Name=pglW {ECO:0000313|EMBL:PWI10543.1};
GN ORFNames=DIZ27_11185 {ECO:0000313|EMBL:PWI10543.1};
OS Streptomyces sp. NWU339.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2185284 {ECO:0000313|EMBL:PWI10543.1, ECO:0000313|Proteomes:UP000245372};
RN [1] {ECO:0000313|EMBL:PWI10543.1, ECO:0000313|Proteomes:UP000245372}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NWU339 {ECO:0000313|EMBL:PWI10543.1,
RC ECO:0000313|Proteomes:UP000245372};
RA Adegboye M.F., Lobb B., Babalola O., Doxey A.C., Ma K.;
RT "Draft genomes of two novel cellulolytic Streptomyces strains isolated from
RT South African rhizosphere soils.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI10543.1}.
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DR EMBL; QFRK01000007; PWI10543.1; -; Genomic_DNA.
DR OrthoDB; 3404503at2; -.
DR Proteomes; UP000245372; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011528; NERD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR NCBIfam; NF033442; BREX_PglW; 1.
DR PANTHER; PTHR48011; CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED; 1.
DR PANTHER; PTHR48011:SF4; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR Pfam; PF08378; NERD; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:PWI10543.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000245372};
KW Transferase {ECO:0000313|EMBL:PWI10543.1}.
FT DOMAIN 202..496
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 529..793
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 565
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1454 AA; 160787 MW; 58217DB29A4AFF17 CRC64;
MPKPGPVKPA QQWSQERPSP YSWEQDALDH VRRLMPAAEP YRAWATFSFT AQSGRVNECD
LLIAVPAGLF LVEIKSHPGE LHNTGSTWNF RGKDRTRTLN NPLHFNDLKS KELRSQLQWA
ARKLYRSDRM VPRIEPAVFL SAPDLVSHLD EVQRIRVYGR DDGASGLNRI WQDFLGLPPE
RPERRVTEEF SRHRLPQLLK TIGIRQSTGH LRFGDAWKME PHPLDAGASW EDHLAKRDDG
LAQGEGRVRI YLVSQGATET DRKKTERAAR REYQVLQGVT HRGIADAMEL RDHEGGPAIL
FRHRHTDLRL DQYLDTYGDK LTPEIRLDLV RQLAEAVRYA HSRSLYHRAL AARSVYVSFR
GEGAHPELRI TDWQTAARDF DSNATFFRSI GGSALDATLI EDAAHVYLAP ETDLPSPEPG
DLDIFGLGAV SYLILTGKPP APQRSVLKER LRTESGLHLF AVADGVSDAL DALVFKATRA
DVNDRLSSAE EFLDLLDEAE RAGTVPDSVA TPAVDPLEAL PGQALDEEWS VRRVLGTGAT
ARALLVERAV EDDDGTIRVE ERVFKVALDE QKADRLRAEE RALKLVGGGA VVQLRGDGLR
EIGSRTVLQL EYAGEQSLGA RLRGTGQLTY DDLENFGEDL FLALDQLAAH GVRHRDIKPD
NLGIQRRKDF TWQLKLFDFS LTDASDRDVK AGTRGYLDPF LGSVRRPHFD DHAERYAAAV
TLHEMASGER PLWGDGRIDP LTNESAELHI AGEVFYRPLQ SGLTAFFRRA LHRDIEHRFD
TLRQMKDAWQ KVFRDADTDR PPTTPSTVGT EAEDTEQARD RAALAAEDGT ELELAGLSPR
AVTVAAGLGA ATVGQLLDVQ PSVISKARGA GPLVRKELNR RRNQWVAALR GKTAVPAARK
AVSPVKDGEA QAGVTGILSV DDMVDLLTPP SGRKGSRRTD VVCLTLGLPP EDGGLSPLGP
WPVQARIADH LGIKQPPVSR HHRAEIKRWA EAEWLRAVCT ELVEIVANFG RVMTASQAAQ
ELRALHGAQD DTPERVLARA LAVVRAAVEA ETREEEGHEP RLAVHRRGDT VLLASESLPG
TDDPNPRELA DYAAELGASA EKLADREPLP GRAEVVRELR AVPVPESFAP LADTRLVQLA
TAMASSVVRH TPRLELYRRD LSLERALRIS QAGAGVRADR GITATELVAR VRARFPDLDV
LTDGREPTPV VLEDALQAAR FDLRHDEEAG RFLPPLPRST GPWSSTGSVT SMLPPVRSVA
RREPEDPHGE LREQLTESAR RGGFLALTVK AARLQGTAET IAARFPVVPV DLGALFLREF
RRLVEEKGQD WRTVLRADAA SAPGRVKPGL ATFVRVVWQR VADDLAARST EPRTVFFLHD
AGLIARYWDE GGRTFLVTLQ GAARRPSQGP HGLWLLCPME SRTQDPHLDG QPVEALRNDG
EVAYLAGGFL KQPA
//
