ID A0A2U2ZRF8_9ACTN Unreviewed; 405 AA.
AC A0A2U2ZRF8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Acetyl-CoA C-acyltransferase {ECO:0000313|EMBL:PWI14874.1};
GN ORFNames=DI272_12415 {ECO:0000313|EMBL:PWI14874.1};
OS Streptomyces sp. Act143.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2200760 {ECO:0000313|EMBL:PWI14874.1, ECO:0000313|Proteomes:UP000245455};
RN [1] {ECO:0000313|EMBL:PWI14874.1, ECO:0000313|Proteomes:UP000245455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Act143 {ECO:0000313|EMBL:PWI14874.1,
RC ECO:0000313|Proteomes:UP000245455};
RA Valanrebinro G., Kumari S., Rameshkumar N.;
RT "Actinomycin D producing novel Streptomyces isolated from the rhizosphere
RT of saline tolerant kaipad rice and its draft genome analysis.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI14874.1}.
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DR EMBL; QFRX01000001; PWI14874.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2ZRF8; -.
DR OrthoDB; 3204099at2; -.
DR Proteomes; UP000245455; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:PWI14874.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245455};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:PWI14874.1}.
FT DOMAIN 8..266
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 275..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 405 AA; 43251 MW; 2A38444146CB1C0C CRC64;
MPRTVRDVVF VDGVRTPFGK AGPKGIYHET RADDLVVKAI RELLRRNPAL EPAKIDEVAI
AATTQIGDQG LTIGRTAGIL AGLPQSVPGY SIDRMCAGAL TAVTTVAGSV AFGAYDVAIA
GGVEHMGRHP MGEGVDPNPR FVSEKLVDES ALFMGMTAEN LHDRYPTITK QRADEYAVRS
QEKAAKAYAN GKIQADLVPI SVRRTNPEAG ETGWGLVTAD EPMRPGTTLE NLSGLKTPFR
VHGRVTAGNA AGLNDGATAS IIASEDFARE NNLPVKMRLV SYSFAGVEPE VMGYGPIPAT
EKALAQAGLT IDDIGLFEIN EAFAVQVLAF LEHYGIADDD ARVNQYGGAI AFGHPLASSG
VRLMTQLARQ FEEQPHVRYG LTTMCVGFGM GATVIWENPH FEGDK
//
