ID A0A2U3BYH7_9ACTN Unreviewed; 327 AA.
AC A0A2U3BYH7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:PWI41846.1};
GN ORFNames=CK485_23890 {ECO:0000313|EMBL:PWI41846.1};
OS Streptomyces sp. ICBB 8177.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=563922 {ECO:0000313|EMBL:PWI41846.1, ECO:0000313|Proteomes:UP000245673};
RN [1] {ECO:0000313|EMBL:PWI41846.1, ECO:0000313|Proteomes:UP000245673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICBB 8177 {ECO:0000313|EMBL:PWI41846.1,
RC ECO:0000313|Proteomes:UP000245673};
RX PubMed=29773836; DOI=10.1038/s41598-018-26179-w;
RA Pavlikova M., Kamenik Z., Janata J., Kadlcik S., Kuzma M., Najmanova L.;
RT "Novel pathway of 3-hydroxyanthranilic acid formation in limazepine
RT biosynthesis reveals evolutionary relation between phenazines and
RT pyrrolobenzodiazepines.";
RL Sci. Rep. 8:7810-7810(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI41846.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NSKH01000023; PWI41846.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U3BYH7; -.
DR OrthoDB; 4190732at2; -.
DR Proteomes; UP000245673; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08241; QOR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR43677:SF3; PROSTAGLANDIN REDUCTASE 3; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245673}.
FT DOMAIN 13..324
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 327 AA; 33942 MW; 6F1F1DB594860B25 CRC64;
MKAWRVHSNG EPRAAMRLDE VERPTAGPGQ VLVRVRAANV NFPDALLCRG QYQIRPPLPF
TPGVELCGEV VTAEPSTGFR EGDRVISPAA LPGGAFAEYA VVDAATVLAA PEALDDAEAA
ALHIGYQTGW FGLHRRAALK AGETLLVHAA AGGVGSAAVQ LGKAAGATVI GVAGGPGKAD
VARKLGCDVV VDRRSEDFVA VVKEVTGGRG ADVVYDPVGG EAYTRSTKCV AFEGRIVVVG
FTSGTIPAPG LNHALVKNYA ILGLHWGLYN THDPAAIRHC HEELTRLATD GAVRPLVSER
VPLTGAADAV QRVADGTTTG RVVVVND
//
