ID A0A2U3C254_9ACTN Unreviewed; 119 AA.
AC A0A2U3C254;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Histidine triad nucleotide-binding protein {ECO:0000313|EMBL:PWI43092.1};
GN ORFNames=CK485_12870 {ECO:0000313|EMBL:PWI43092.1};
OS Streptomyces sp. ICBB 8177.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=563922 {ECO:0000313|EMBL:PWI43092.1, ECO:0000313|Proteomes:UP000245673};
RN [1] {ECO:0000313|EMBL:PWI43092.1, ECO:0000313|Proteomes:UP000245673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICBB 8177 {ECO:0000313|EMBL:PWI43092.1,
RC ECO:0000313|Proteomes:UP000245673};
RX PubMed=29773836; DOI=10.1038/s41598-018-26179-w;
RA Pavlikova M., Kamenik Z., Janata J., Kadlcik S., Kuzma M., Najmanova L.;
RT "Novel pathway of 3-hydroxyanthranilic acid formation in limazepine
RT biosynthesis reveals evolutionary relation between phenazines and
RT pyrrolobenzodiazepines.";
RL Sci. Rep. 8:7810-7810(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI43092.1}.
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DR EMBL; NSKH01000018; PWI43092.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U3C254; -.
DR OrthoDB; 9784774at2; -.
DR Proteomes; UP000245673; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01276; PKCI_related; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR001310; Histidine_triad_HIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR23089:SF33; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1; 1.
DR PANTHER; PTHR23089; HISTIDINE TRIAD HIT PROTEIN; 1.
DR Pfam; PF01230; HIT; 1.
DR PRINTS; PR00332; HISTRIAD.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245673}.
FT DOMAIN 10..119
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 103..107
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 105
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ SEQUENCE 119 AA; 12524 MW; 213A1013117B2D81 CRC64;
MAGEPQADCL FCKIVAGDVP ATIVRETETT VAFRDINPQA PTHVLVIPKE HHRDAATLAA
EAPQAAADVL REAREVAVHD GVEATGYRVV FNTGSGAGQT VFHAHAHVLG GRGLNWPPG
//
