ID A0A2U3C2U6_9ACTN Unreviewed; 416 AA.
AC A0A2U3C2U6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=CK485_14275 {ECO:0000313|EMBL:PWI43319.1};
OS Streptomyces sp. ICBB 8177.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=563922 {ECO:0000313|EMBL:PWI43319.1, ECO:0000313|Proteomes:UP000245673};
RN [1] {ECO:0000313|EMBL:PWI43319.1, ECO:0000313|Proteomes:UP000245673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICBB 8177 {ECO:0000313|EMBL:PWI43319.1,
RC ECO:0000313|Proteomes:UP000245673};
RX PubMed=29773836; DOI=10.1038/s41598-018-26179-w;
RA Pavlikova M., Kamenik Z., Janata J., Kadlcik S., Kuzma M., Najmanova L.;
RT "Novel pathway of 3-hydroxyanthranilic acid formation in limazepine
RT biosynthesis reveals evolutionary relation between phenazines and
RT pyrrolobenzodiazepines.";
RL Sci. Rep. 8:7810-7810(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI43319.1}.
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DR EMBL; NSKH01000018; PWI43319.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U3C2U6; -.
DR OrthoDB; 3196337at2; -.
DR Proteomes; UP000245673; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd07732; metallo-hydrolase-like_MBL-fold; 1.
DR Gene3D; 3.40.50.10710; Metallo-hydrolase/oxidoreductase; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR042173; RNase_J_2.
DR PANTHER; PTHR43694; RIBONUCLEASE J; 1.
DR PANTHER; PTHR43694:SF1; RIBONUCLEASE J; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW Nuclease {ECO:0000256|ARBA:ARBA00022839};
KW Reference proteome {ECO:0000313|Proteomes:UP000245673};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 14..243
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 416 AA; 44508 MW; 62FCAC5D33F1AE0A CRC64;
MVLIEFWGGL GVIGGSKITI RDGGHRVMLD IGMDIPSGAD LFRLPVRPRP ARELADRLRV
GAAPRVPGLF DPAVLAEGDP LAAPAEPTSV FVSHPHIDHV GLAGWVRPEV PVYAHTDAVD
VLRALDASGQ GLPGGDPEWR RLASGEQVAV GPMRVECVPV DHDVPGASGY LVHTSGGTLA
FTGDIRFHGR HPERSWAFAD RAAACDVLVT EGTTLGWDMS GAVRTEDDVA RDFATALAVT
PGLVLLSLYP RDVERVREFL ALAKDAGRTV LWPARVAAFL RELGVPDVAE GLPRGDPGGH
VVVPDPDDLP ALLDLPVGPG HPDSVFVHAN GEPLGPFEPR WAPFTDWLAA LSVPLRQIGS
SGHATQDDLH VLLERTRPRV LFPIHTTAPT RLHPPTGTTR VIARYGVGYD MEGREV
//
