ID A0A2U3C7E0_9ACTN Unreviewed; 485 AA.
AC A0A2U3C7E0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Potassium/proton antiporter {ECO:0000313|EMBL:PWI44942.1};
GN ORFNames=CK485_07080 {ECO:0000313|EMBL:PWI44942.1};
OS Streptomyces sp. ICBB 8177.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=563922 {ECO:0000313|EMBL:PWI44942.1, ECO:0000313|Proteomes:UP000245673};
RN [1] {ECO:0000313|EMBL:PWI44942.1, ECO:0000313|Proteomes:UP000245673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICBB 8177 {ECO:0000313|EMBL:PWI44942.1,
RC ECO:0000313|Proteomes:UP000245673};
RX PubMed=29773836; DOI=10.1038/s41598-018-26179-w;
RA Pavlikova M., Kamenik Z., Janata J., Kadlcik S., Kuzma M., Najmanova L.;
RT "Novel pathway of 3-hydroxyanthranilic acid formation in limazepine
RT biosynthesis reveals evolutionary relation between phenazines and
RT pyrrolobenzodiazepines.";
RL Sci. Rep. 8:7810-7810(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI44942.1}.
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DR EMBL; NSKH01000004; PWI44942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U3C7E0; -.
DR OrthoDB; 9810759at2; -.
DR Proteomes; UP000245673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..485
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 485 AA; 50266 MW; 19A352C742B5BB9D CRC64;
MTNAENLGLT ILVLSVVVML AALSNRVSER LRVPAPFIFL VCSAAASDAL PVLNRRVPVS
LVEQVVTVAL VVVLFDGGLG IGWRRFRGAV APIVTLGVVG TVLTTGAVAL LSHYVCDLGW
RTSLVLGAAL APTDPAVVFS VLGRREVTGR TGTVLEGESG ANDPVGISLM VALLGASGSV
GQQAGHVVVT FAEQMAVGVA VGVGGGFALL WFMRKVSLPA AGLHPVRALA GAMAIYGVAT
VAHGSGFLAV LVAGVLIGDA TMPYRLEVRQ VFGALSSLAE IVVFIALGLT VGLRTLADGW
AWLIGLILAV LLAVVVRPLL VGPLLLPVRM RAGERGFVLW AGLKGAVPIL LGAFAITSGV
PDAKRIYEII FMVVAFSVLV QGGSVGWAAR KLGVPMRTTP STPWTFGVRL PHEPSSTLHV
VEAGSDADGA TLEDLVINGD MWVSAALRGG HLLPMAPDTV VRAGDEVLLL RRPAEPDEPQ
DPPRA
//