ID A0A2U3C8T1_9ACTN Unreviewed; 1285 AA.
AC A0A2U3C8T1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ABC transporter ATP-binding protein {ECO:0000313|EMBL:PWI45428.1};
GN ORFNames=CK485_04705 {ECO:0000313|EMBL:PWI45428.1};
OS Streptomyces sp. ICBB 8177.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=563922 {ECO:0000313|EMBL:PWI45428.1, ECO:0000313|Proteomes:UP000245673};
RN [1] {ECO:0000313|EMBL:PWI45428.1, ECO:0000313|Proteomes:UP000245673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICBB 8177 {ECO:0000313|EMBL:PWI45428.1,
RC ECO:0000313|Proteomes:UP000245673};
RX PubMed=29773836; DOI=10.1038/s41598-018-26179-w;
RA Pavlikova M., Kamenik Z., Janata J., Kadlcik S., Kuzma M., Najmanova L.;
RT "Novel pathway of 3-hydroxyanthranilic acid formation in limazepine
RT biosynthesis reveals evolutionary relation between phenazines and
RT pyrrolobenzodiazepines.";
RL Sci. Rep. 8:7810-7810(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWI45428.1}.
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DR EMBL; NSKH01000003; PWI45428.1; -; Genomic_DNA.
DR OrthoDB; 9806127at2; -.
DR Proteomes; UP000245673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18543; ABC_6TM_Rv0194_D1_like; 1.
DR CDD; cd18546; ABC_6TM_Rv0194_D2_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221:SF658; ABC TRANSPORTER B FAMILY MEMBER 29, CHLOROPLASTIC; 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:PWI45428.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 832..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..333
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 368..602
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 723..1005
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1041..1275
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 137034 MW; 63BBD79880E538B4 CRC64;
MAATTRTANT TERPGGDPDG PGDGRRRSTG GRPGQGWLRR ITADSWRYRR AVLLALGASL
VGMAVTALVP LLPRLIIDDV VAGHTGSVGL WAALMVLAAL AVYASTYVRR YYGGRLALDV
QYDLRTAMFR TLARLDGARQ DALDTGQVVG RATSDLQLIQ GLLFMIPVML GNLLLFVMSL
VVMAVLSPLL TLIALAVAPA LWFLANRSRT RLFPATWYAQ GQAAAVAGVV DGAVTGVRVV
KGFGQEAQEE QKLRRVSLRL FAARLRTVRL NARYNPALQA VPALGQVAML ALGGWMAVHH
QITLGTFVAF STYLAQLTGP VRMLTMMLTV GQQARAGVER VYELIDTEPV ITESPHAREL
PRDADADIEF DDVTFGYDPD RPVLEHLSLR VEPGETLAVV GASGSGKSTV SLLLPRFYDV
SGGAVRVGGT DVRDLTLDSL RAAIGLVPED SFLFSDSVRA NIAYGRPDAT DAEVEAAARA
AQAHGFISAL PKGYDTVVGE QGLTLSGGQR QRVALARAVL TDPRLLLLDD ATSAVDARVE
AEIHDALREV MRGRTTLLIA HRRSTLALAD RVAVLDHGHL ADVGTHDELQ ERCALYRRLL
TDPDELAGDD AWSPDPAGRV RIVGEDGADA RGGAVDGATP ELWPRSDRGA EGEAQVGATA
AAPAGPGMAG ALAGMPATPE LLARVAALPP ATDTPDIDET VVRAAEPHFG LRAMLRGFTA
PLLISLALVA ADALGGLLLP ILIRHGIDQG VDRLALGAVW SAAGLALLVV LAQWAAEVGE
NQMTGRTGER VLYSLRLKIF AQLQRLGLDY YERELTGRVM TRMTTDVDAL SSFLQTGLVT
AVVSLLTFFG ILVALLALDV ELALVVFVTL PPLIAATVVF RRKSVRAYGL ARDRVGVVNA
DLQEHVAGLR VVQAFRGERA GARRFAERSD AYRQARVRGQ WYISVYFPFV QFLSSVAAAL
VLIVGAGRVG DGTLTAGALV AYLLYIDLFF SPVQQLSQVF DGYQQASVSL GRIAELLRLP
TATPLPQHPV PVPGTGLRGE ITFDDVHFAY GDGEEALAGI DLCVPAGQTV AFVGETGAGK
STLVKLVARF YDPTGGAVRV DGLDLRDLDL TGYRRRLGVV PQEPYLFPGT IRDAIAYGRP
DATDAEVEAA ARAVGAHEMV ASLADGYLHR VGERGRNLSA GQRQLIALAR AELVDPDVLL
LDEATAALDL ATEAVVNAAA DRLAVRRTTL VVAHRLTTAA RADRVVVMDH GRVVEDGTHA
ELLAAGGRYA ELWRTFAGEP ADTAA
//
