ID A0A2U3MZV3_9GAMM Unreviewed; 495 AA.
AC A0A2U3MZV3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=fixL {ECO:0000313|EMBL:SPL70903.1};
GN ORFNames=KPC_2081 {ECO:0000313|EMBL:SPL70903.1};
OS Acinetobacter stercoris.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=2126983 {ECO:0000313|EMBL:SPL70903.1, ECO:0000313|Proteomes:UP000245974};
RN [1] {ECO:0000313|Proteomes:UP000245974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KPC-SM-21 {ECO:0000313|Proteomes:UP000245974};
RA Blom J.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; OOGT01000089; SPL70903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U3MZV3; -.
DR SMR; A0A2U3MZV3; -.
DR InParanoid; A0A2U3MZV3; -.
DR OrthoDB; 1931120at2; -.
DR Proteomes; UP000245974; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13188; PAS_8; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000313|EMBL:SPL70903.1}.
FT DOMAIN 3..46
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 132..195
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 276..490
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 495 AA; 56205 MW; 33A67E10E03E17CE CRC64;
MTSLNYYQTI FDKAGDAIFV HDIGSVQFMD VNEAAVVLTG YSKSELTHMN VEKISAFHQG
FDLHHALKKV QQVAASTDEA ITFEWLIESK DKQQIPVEVC LKTVEIEQQP KLLALVRNIS
EIKKYQYALQ SKDQYFKILL ENSADGIAIL DPQGKLLYAS ASLQRILGYR DRFVLNKNVL
SVIHPNDRTA IRQTLFKHPT QIYDGVLHYR ILHHNGEWHH HEASFKNLLN HPNIQGILIN
YRDITERIQA EQIARTREKQ LGHMSRCKTM GELATALAHE LNQPLAALNN YVGGSIIRIQ
NGLANTPETI AALNSALDQT QRVNRIIHSM RSFLRKGEAN FQHHSLNSLI QDLHPLIRLK
AEQGDCKVHY ELNVHPLYIQ ADETLFSQVI INLVFNAVDA LQKNPVSQRD VYIRTWQYNQ
YARIAIADNG PGLQGQNPEQ LFESFYSSKS DSMGIGLTLS RSIIESHQGY LWVCEGDTGA
IFNISLAAKE RAKCM
//
