ID   A0A2U3P3I2_9MYCO        Unreviewed;       288 AA.
AC   A0A2U3P3I2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SPM38311.1};
DE   Flags: Fragment;
GN   ORFNames=MNAB215_488 {ECO:0000313|EMBL:SPM38311.1};
OS   Mycobacterium numidiamassiliense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1841861 {ECO:0000313|EMBL:SPM38311.1, ECO:0000313|Proteomes:UP000240424};
RN   [1] {ECO:0000313|EMBL:SPM38311.1, ECO:0000313|Proteomes:UP000240424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB215 {ECO:0000313|EMBL:SPM38311.1,
RC   ECO:0000313|Proteomes:UP000240424};
RG   Urmite Genomes;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FUEZ01000003; SPM38311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U3P3I2; -.
DR   STRING; 1841861.GCA_900157365_04691; -.
DR   Proteomes; UP000240424; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240424}.
FT   DOMAIN          17..188
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          192..288
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   SITE            146
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:SPM38311.1"
SQ   SEQUENCE   288 AA;  31769 MW;  7A49A4D66BA01DF9 CRC64;
     VTGSYTYTFE DIQHRPVAVV GAGTLGRRIA LMFATRGGPV RIYARRPEQL AEASDYVSQT
     LPRVLEQRGS GQAGVVTGVA TLEEALDDAW LVVESVPERL DIKIPLWGQI DHLAQPGTIF
     ATNSSSYPSR LMAENVSDKS RLCNMHFYMP PELNAIDLMS DGETDRGLLD TLLRVLPEFG
     VHPFEARKEC TGFIFNRIWA AIKREALAVV AEGVARPEDV DGMFTINLGV PAGPFRMMDL
     VGLDVVLDIE NHYAAEFPHL PENVRELLQA YVDAGKLGIK TGEGFYSY
//