ID   A0A2U3P5R9_9MYCO        Unreviewed;       422 AA.
AC   A0A2U3P5R9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=H+/Cl-antiporter ClcA {ECO:0000313|EMBL:SPM39104.1};
DE   Flags: Fragment;
GN   ORFNames=MNAB215_1286 {ECO:0000313|EMBL:SPM39104.1};
OS   Mycobacterium numidiamassiliense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1841861 {ECO:0000313|EMBL:SPM39104.1, ECO:0000313|Proteomes:UP000240424};
RN   [1] {ECO:0000313|EMBL:SPM39104.1, ECO:0000313|Proteomes:UP000240424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB215 {ECO:0000313|EMBL:SPM39104.1,
RC   ECO:0000313|Proteomes:UP000240424};
RG   Urmite Genomes;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FUEZ01000003; SPM39104.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U3P5R9; -.
DR   STRING; 1841861.GCA_900157365_05489; -.
DR   Proteomes; UP000240424; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd01033; ClC_like; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240424};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:SPM39104.1"
SQ   SEQUENCE   422 AA;  44144 MW;  2D8468314BA14D77 CRC64;
     VAFQGRSKHV DFFCAVVIVG LLAGVAGLST TFVLRFVQHL TYHYSFGTML TGVSGSSPVR
     RVLGPMAGAA LAGIGWWILR RRSQVPPLAG IIARHERIPR LSWSVDAMLQ VLLVGSGASL
     GREGAPRQFA AVLGDLATGW LKRLSARDRE ILLSCAAGAG LGAVYAVPLA GALFSVRIML
     NTWHPRAVGA ALLTSSLAVA VGSVDTRDQP ILDWPIGEST YLLTAHGLMM APLALGVGLA
     FNRIMAAARP ARQIRSWVLV PALAGAGLVM GVCSHWWPEL PGNGRSILTV SLASGLTLSA
     AVAILILKPL LTALFLRAGG AGGMLTPSLA TGAAAGASMV LLINWVTGVH LHVPAVSLAG
     AAGVLAVTQG SPIWAAIFVW ELARPPLWLF LVFLLTATGA HGLNVLLRRR GVRAQKQDER
     VG
//