ID   A0A2U3PFK0_9MYCO        Unreviewed;       762 AA.
AC   A0A2U3PFK0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=isocitrate lyase {ECO:0000256|ARBA:ARBA00012909};
DE            EC=4.1.3.1 {ECO:0000256|ARBA:ARBA00012909};
DE   AltName: Full=Isocitrase {ECO:0000256|ARBA:ARBA00031022};
DE   AltName: Full=Isocitratase {ECO:0000256|ARBA:ARBA00031921};
GN   ORFNames=MNAB215_4774 {ECO:0000313|EMBL:SPM42554.1};
OS   Mycobacterium numidiamassiliense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1841861 {ECO:0000313|EMBL:SPM42554.1, ECO:0000313|Proteomes:UP000240424};
RN   [1] {ECO:0000313|EMBL:SPM42554.1, ECO:0000313|Proteomes:UP000240424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB215 {ECO:0000313|EMBL:SPM42554.1,
RC   ECO:0000313|Proteomes:UP000240424};
RG   Urmite Genomes;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate = glyoxylate + succinate;
CC         Xref=Rhea:RHEA:13245, ChEBI:CHEBI:15562, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:36655; EC=4.1.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00023531};
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DR   EMBL; FUEZ01000004; SPM42554.1; -; Genomic_DNA.
DR   RefSeq; WP_077080976.1; NZ_FUEZ01000004.1.
DR   AlphaFoldDB; A0A2U3PFK0; -.
DR   STRING; 1841861.GCA_900157365_03094; -.
DR   OrthoDB; 8629576at2; -.
DR   Proteomes; UP000240424; Unassembled WGS sequence.
DR   GO; GO:0004451; F:isocitrate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd00377; ICL_PEPM; 1.
DR   Gene3D; 1.10.10.850; -; 1.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR039556; ICL/PEPM.
DR   InterPro; IPR006254; Isocitrate_lyase.
DR   InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR   PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR   Pfam; PF00463; ICL; 2.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:SPM42554.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240424}.
SQ   SEQUENCE   762 AA;  84903 MW;  2455E9ACC4AF02A8 CRC64;
     MAIIDADTEV PAPFEQDVAA TQRYMDDPRF AGIIRLYTAR QVVEQRGTIP TDYTVAREAA
     AAFYPRLREL FAQKKSITTF GPYSPGQAVS MKRMGIEGIY LGGWATSAKG STTEDPGPDL
     ASYPLSQVPE DAAVLVRALL TADRNQEYQR LQMNEQQRAG AKQYDYRPFI IADADTGHGG
     DPHVRNLIRR FVEVGVPGYH IEDQRPGTKK CGHQGGKVLV PSDEQIKRLN AARFQLDVMR
     VPGIIVARTD AEAANLIDSN SDERDQAFLL GATNLDIPSY KGCFLALLRR FHELGVKDLN
     GHLLYALADG EYGIANAWLE RQGILGLVSE AVNTWREDGQ KSIDDLFDQV ESRFIAAWED
     DAGLMTYSDA VAEVLSFGES EDEPASMSPD EWRQFAARTS HYAARAKARE LGAAPDWSPE
     LARTPEGYYQ VRGGIPYAIA KSLAAAPFAD ILWMETKTAD LADAREFAEA IHAEFPDQML
     AYNLSPSFNW DTTGMTDEEM KQFPVELGKM GFVFNFITYG GHQIDGVAAE EFATSLQQDG
     MLALARLQRK MRLVESPYRT PQTLVGGPRS DAALAASSGR TATTKAMGKG STQSQHLVQT
     EVPKKLLEEW LTLWSEHYQL GEKLRVTLRP RRAGSDVLEL GILGEDGEQL ANVIVDPIKD
     RHGRSILQVR DQNTFAEKLR QKRLMTLIHL WLVNRFKADA VYYVTPTEDN LYQTEKMKSH
     GIFSEVYPEV GEIIVAEVNK PRIAELLKSD RVALRKLITK ES
//