ID   A0A2U3PGM2_9MYCO        Unreviewed;       978 AA.
AC   A0A2U3PGM2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
DE   Flags: Fragment;
GN   ORFNames=MNAB215_5111 {ECO:0000313|EMBL:SPM42891.1};
OS   Mycobacterium numidiamassiliense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1841861 {ECO:0000313|EMBL:SPM42891.1, ECO:0000313|Proteomes:UP000240424};
RN   [1] {ECO:0000313|EMBL:SPM42891.1, ECO:0000313|Proteomes:UP000240424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB215 {ECO:0000313|EMBL:SPM42891.1,
RC   ECO:0000313|Proteomes:UP000240424};
RG   Urmite Genomes;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; FUEZ01000004; SPM42891.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U3PGM2; -.
DR   STRING; 1841861.GCA_900157365_03431; -.
DR   Proteomes; UP000240424; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   NCBIfam; TIGR00833; actII; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240424};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        304..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        776..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        801..823
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        829..852
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        873..896
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        902..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          65..393
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          617..948
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:SPM42891.1"
SQ   SEQUENCE   978 AA;  106677 MW;  824E52B0D023F0A3 CRC64;
     VTDNTSDTDE IPVAPRTEVE RKPRIARTIR VLALPIVVIW LLIAVGVNVF VPQLEAVAED
     VSVPLSPSDA PSVTGMKHIG QKFNEYDSDN LVLVTLVGDK PLGPDAHQYY SDLVKKLRQD
     TKHVEHALDF WGQRFTASGV ESYDHKSAYV QVNLRGDQGG AVGDKSVDSV RQIVADSKPP
     PGVKAYVAGQ GALTDDTIVV GNASLFKMTI ITVIIIAIML MFVYRSIGTV LLTMVILFVG
     LATGRGVVAL LGDTGIMGLS TFAVNLLTAL AIAAGTDYAI FMVGRYQEGR ERGLDREAAY
     YDTFAGVTKV VLGSGLTIVG ALACLHFTRL PYFSSLAFPC AIGLLVVVAA GVTLTPALIV
     FASGFGLFDP KRKFNYTRWR RLATAIVRWP APILATSVIL AIVGALGLMG FNPRYNDLYY
     LPQSASSVKA YTAADQHFTQ ARLNPDLLMI ESDHDLRNPT DMLVLDKIAG AIFRVPGIER
     VQSITRPLGP PIQDGSIPFQ LSVQTAPIRD NLNYLRARVG DIKKITGFLD TQIDLLERQY
     KVTQDLANAA DDSSKTTGDT AAITDEIRDH IADFDDFWRP IRSYFYWEKH CYDIPICWSL
     RSLFDALDGF DKLAEQFHKL TKDLGDTARA TRELLAIIPE NIAVSKSIRD TTLTIYSTFD
     SLIDQFDRLT DTNAVMGKSF NDSQVESLFY LPPEIFQNPD FQLGLSLMVS PDGKAARFIV
     THAVDPATTE GIASVNQERQ AAKEALKLTS LQNADIYLGG TAATFYDIAN GAKYDLMIAG
     VASIVLIFII MVVVTRALVA AGVIVGTIVM SLGAAFGFST LIWQHLLNFQ LHWVATEFAL
     IVLLAVGSDY NLMLVSRIEE EIGAGLKTGL IRGMGVTGPV VTAAGVVFAV TMGTMITSDL
     RAIGQFGTTI GIGLLFDTFV VRSLITPSIM TVMGRWFWWP KRVRVRPASQ MLRSVGPRPL
     VRALLYHPPR AAPPDPQA
//