ID   A0A2U3QG73_9BACT        Unreviewed;       670 AA.
AC   A0A2U3QG73;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:SPQ00398.1};
DE            EC=4.2.1.129 {ECO:0000313|EMBL:SPQ00398.1};
DE            EC=5.4.99.17 {ECO:0000313|EMBL:SPQ00398.1};
GN   Name=shc {ECO:0000313|EMBL:SPQ00398.1};
GN   ORFNames=NBG4_220031 {ECO:0000313|EMBL:SPQ00398.1};
OS   Candidatus Sulfobium mesophilum.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Sulfobium.
OX   NCBI_TaxID=2016548 {ECO:0000313|EMBL:SPQ00398.1, ECO:0000313|Proteomes:UP000245125};
RN   [1] {ECO:0000313|Proteomes:UP000245125}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zecchin S.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
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DR   EMBL; OUUY01000067; SPQ00398.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U3QG73; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000245125; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:SPQ00398.1};
KW   Lyase {ECO:0000313|EMBL:SPQ00398.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245125};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          50..335
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          344..659
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   670 AA;  76082 MW;  741E7DFF4FEB37F3 CRC64;
     MDLISGEMSR ILGRYFGFIS TSPAEGENAT FSAGRLDALN EEIARAAART SGNYLGEQHP
     DGYWWYELEA NVTITSEYLM LLHFLGLYDR QRDELIARHI LNNQRPDGTW AIHWGGEGDL
     STTVEAYFAL KLAGFDPDDP PLRKAREFIL KNGGVESCRV FTRIFLALFG EFDWKAIPSI
     PVEVNLMPSW FPMSIYRMSS WARCTFVPLS IVLDLRPVRP IPRGARIREL YKVPDKMPSL
     SPKKLSTFSW KRFFFILDMV IKAAEDTPLR VFRNKAMGFT ERWVRERQEP TGDWGGIQPA
     MVNSILALSS LGHDVSHEPI RKGLEALERF TLEKEEELML QSCISPVWDT ALTSLALLHA
     GLRKDHPQLI KACRWLASKQ IFKKGDWSIK RPGLEPGGWA FEFENSWYPD VDDTAVVLML
     LYRYADDGVI DRAKLDRGLS WILGMQGRDG GWGAFDVDNN MRILNQLPLG DLEAMIDPST
     PDLTGRVLEL LGQIGYGTND RAVKKAIKFL RKTQEGDGSW WGRWGVNHIY GTCAVLCGLG
     AVGESLKAPY VRKAVRWIKD NQNQDGGWGE CCESYADPSL KCRGASTPSQ TAWAMMALMA
     AEQEIVEEVI RGVKYLLKRQ KDDGTWDEEW FTGTGFPKYF MLRYHNYRNC FPLMALGKFC
     QRSRSRGLGQ
//