ID A0A2U3V756_TURTR Unreviewed; 496 AA.
AC A0A2U3V756;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Mucolipin-3 isoform X2 {ECO:0000313|RefSeq:XP_004324824.1};
GN Name=MCOLN3 {ECO:0000313|RefSeq:XP_004324824.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_004324824.1};
RN [1] {ECO:0000313|RefSeq:XP_004324824.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_004324824.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004324824.1; XM_004324776.3.
DR AlphaFoldDB; A0A2U3V756; -.
DR GeneID; 101322878; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..213
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 314..451
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 496 AA; 57561 MW; 6BCDB0ABFC90A29A CRC64;
MANPEAVISS CSSHEEENRC TFNQHTSPSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP
WKLAIQILKM AMVTIQYLQL RNISVGNHAY ENKGTEQSAM AICQHFYKQG NICPGNDTFD
IDPEIETECF FVAPDEPFHV GTLEEKLKLL LDFHRLITVD LQFKLKAINL QTIRHHELPD
CYDFTLTITF DNKAHSGRIK ISLDNDISIR ECKDWHVSGS IQKNTHYMMI FDAFVILICL
ASLILCVRSV VKGLQLQQEF VNFFLLHYKK EVSVSDRMEF VNGWYIMIII SDILTITGSI
LKMEIQAKSL TSYDVCSILL GTSTMLVWLG VIRYLGFFQK YNLLILTLQA ALPNVIRFCC
CAAMIYLGYC FCGWIVLGPY HDKFRSLNMV SECLFSLING DDMFATFANM QQKSYLVWLF
SRIYLYSFIS LFIYMILSLF IALITDTYET IKHYQQDGFP ETELRVFISE CKDLPNSGKY
RLEEEPAVSI FCCCKK
//
