ID   A0A2U3V7R3_TURTR        Unreviewed;       717 AA.
AC   A0A2U3V7R3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE   AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN   Name=MPEG1 {ECO:0000313|RefSeq:XP_004325838.2};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_004325838.2};
RN   [1] {ECO:0000313|RefSeq:XP_004325838.2}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_004325838.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC       membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MPEG1 family.
CC       {ECO:0000256|ARBA:ARBA00007256}.
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DR   RefSeq; XP_004325838.2; XM_004325790.3.
DR   AlphaFoldDB; A0A2U3V7R3; -.
DR   STRING; 9739.ENSTTRP00000007186; -.
DR   GeneID; 101326081; -.
DR   InParanoid; A0A2U3V7R3; -.
DR   OrthoDB; 4221421at2759; -.
DR   Proteomes; UP000245320; Chromosome 8.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd22579; MPEG1_P2; 1.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR039707; MPEG1.
DR   PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..717
FT                   /note="Macrophage-expressed gene 1 protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015750891"
FT   TRANSMEM        656..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..345
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
SQ   SEQUENCE   717 AA;  79045 MW;  B1BAD78C8EF5FB74 CRC64;
     MNSVRGAVLI WAVAAWAKMN KPLGDTDEDG FQKCKNALKL PVLAVLPGGG WDNLRNVDMG
     RVMNLTYTYC RTTEDGQYIV PDEVFTIPQK ESNLEMNSKI LESWENYQSS TSYSINMELS
     LFSKVNGKFS PEFQRMKTLQ VKDQAVTTQV QVRNLVYTVK INPDAELSWG FKKELMDISE
     RLEKNQTRMA TYLAELLVLN YGTHVITSVD AGAALIQEDH IRSSLLQDSQ NSRSAVTASA
     GITFLNIVNF KFEENHTSQN AFTKSYLSNR TDSRVQSIGG LPFYPGITLQ TWQQGITNHL
     VAMDRAGLPL YFFINPDRLP DLPGPLVKKL SNTVETAVRR YYTFNTYPGC TDVNSPNFNF
     QANMDDGSCE GKMTNFSFGG VYQECTQFSG NEVVQLCRNL EQKNPLTGDF SCPSGYTPVQ
     LLSQTHEEGY NHLECSRKCT LLIFCKTVCE DVFRVAKAEF RALWCAASGQ VPENSGLLFG
     GLFSDKSINP LTNAQSCPAG YFPLRLFENL KVCASQDYEL GYRFSVPFGG FFSCAVGNPL
     VDSVMDKDLG APSLKKCPGG FSQHLALISD GCQVSYCVKA GLFTGGSLPP VRLPPYTQPP
     LMSQAATNTV LVTNLETASS WIKDSQTHQW RLGEPLELRR AMKVIHGDGS GLSGGAAAGV
     TLGITTVLAA VIALAIYGTR KYKKRGYQAV QDERQSLVTD TAVHGDALDQ EQVQSPA
//