ID A0A2U3V7Y4_TURTR Unreviewed; 218 AA.
AC A0A2U3V7Y4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein N-lysine methyltransferase METTL21A {ECO:0000256|ARBA:ARBA00040801};
DE AltName: Full=Methyltransferase-like protein 21A {ECO:0000256|ARBA:ARBA00041632};
GN Name=METTL21A {ECO:0000313|RefSeq:XP_004326197.1,
GN ECO:0000313|RefSeq:XP_033715745.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_004326197.1};
RN [1] {ECO:0000313|RefSeq:XP_004326197.1, ECO:0000313|RefSeq:XP_033715745.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_004326197.1,
RC ECO:0000313|RefSeq:XP_033715745.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961;
CC Evidence={ECO:0000256|ARBA:ARBA00024593};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193;
CC Evidence={ECO:0000256|ARBA:ARBA00024593};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL21
CC family. {ECO:0000256|ARBA:ARBA00038029}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004326197.1; XM_004326149.3.
DR RefSeq; XP_033715745.1; XM_033859854.1.
DR STRING; 9739.ENSTTRP00000003052; -.
DR GeneID; 101319994; -.
DR OrthoDB; 5346852at2759; -.
DR Proteomes; UP000245320; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF14; PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_004326197.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_004326197.1}.
SQ SEQUENCE 218 AA; 24501 MW; 789523EB8D01D013 CRC64;
MALVPYEETA EKGLQRFHKP LATFSLANHT IQIRQDWKQL GVAAVVWDAA IILATYLEMG
AVELRGCSAV ELGAGTGLVG MVAALLGAHV TITDRKVALE FLKSNVQANL PPHIQPRAVV
KELTWGQNLG SFSPGEFDLI LGADIIYLEE TFTDLLQTLE HLCSNHSVIL LACRIRYERD
HNFLAMLERQ FTVRKVHYDP EKDVHIYKAQ RRSLREDL
//
