ID A0A2U3V8B1_TURTR Unreviewed; 666 AA.
AC A0A2U3V8B1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc finger protein 599 isoform X1 {ECO:0000313|RefSeq:XP_004326889.1};
GN Name=ZNF599 {ECO:0000313|RefSeq:XP_004326889.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_004326889.1};
RN [1] {ECO:0000313|RefSeq:XP_004326889.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_004326889.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004326889.1; XM_004326841.3.
DR AlphaFoldDB; A0A2U3V8B1; -.
DR STRING; 9739.ENSTTRP00000002745; -.
DR GeneID; 101332937; -.
DR InParanoid; A0A2U3V8B1; -.
DR OrthoDB; 5250644at2759; -.
DR Proteomes; UP000245320; Chromosome 19.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24390; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24390:SF245; ZINC FINGER PROTEIN 383-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 87..158
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 277..304
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 305..332
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 333..360
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 361..388
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 389..416
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 417..444
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 445..472
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 473..500
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 501..528
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 529..556
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 557..584
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 585..612
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 613..640
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 641..666
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 76269 MW; 591A338E775E5FF5 CRC64;
MSRDPLSSGL SAEHSPSSFP AFGLRRSRRR LPGPCAHPTP RTLRSQVPPP RAGLRSRLSP
LDRLLSPPLV VPLCPLGPMA APELALVSFE DVAVTFTGEE WRHLDLAQRT LYQEVMLETC
GLLVSLGHPV PKPELIHLLE HGQELRTVKR GLSRSTCTGE KAKPEITELT ASHLVLTEGA
PFEERVTHGA SRHSRLEQAR DQEKLSEMQE GNLRPGTDIH KETCPRKLSH KHDDFETDDS
LYLRVLQERV TTRDALHERD SQEPGGDPVT DARNNLYRCK ECGKGFSKNW ALVRHQQIHA
GVKPYECSEC GKACRYMADF IRHMRFHTGE KPYKCIECGK AFKRRSHLTE HQRIHTGDKP
YECKECGKAF THRSSFIQHN MTHTREKPFL CKECGKAFYY SSSFAQHMRI HTGKKLYKCS
ECGKAFTHRS TFIQHNMTHT GEKPFLCKEC GKAFCLNSSF TQHMRIHTGE KPYECSECGR
AFTHRSTFIR HKRTHTGEKP FECKECGKAF CDSSSLIQHM RIHTGERPYE CSECGKAFTH
HSVFIRHNRT HSGEKPLECK ECAKAFYYSS SFTRHMRIHT GEKPYVCREC GKAFTQPANF
VRHNRIHTGE KPYECKECEK AFCDNFALTQ HMRTHTGEKP FECGECGKAF SHSSSFIHHR
KIHTRV
//
