ID A0A2U3VA39_TURTR Unreviewed; 207 AA.
AC A0A2U3VA39;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Suppressor of IKBKE 1 {ECO:0000256|ARBA:ARBA00041003};
DE AltName: Full=Suppressor of IKK-epsilon {ECO:0000256|ARBA:ARBA00042344};
GN Name=SIKE1 {ECO:0000313|RefSeq:XP_004331028.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_004331028.1};
RN [1] {ECO:0000313|RefSeq:XP_004331028.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_004331028.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC mediated activation of interferon-stimulated response elements (ISRE)
CC and the IFN-beta promoter. May act by disrupting the interactions of
CC IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-
CC kappa-B activation pathways. {ECO:0000256|ARBA:ARBA00037749}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SIKE family.
CC {ECO:0000256|ARBA:ARBA00005537}.
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DR RefSeq; XP_004331028.1; XM_004330980.2.
DR AlphaFoldDB; A0A2U3VA39; -.
DR STRING; 9739.ENSTTRP00000014768; -.
DR GeneID; 101324600; -.
DR InParanoid; A0A2U3VA39; -.
DR OrthoDB; 5396923at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR Pfam; PF05769; SIKE; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
SQ SEQUENCE 207 AA; 23777 MW; 058ACF44A018206D CRC64;
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
IKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKK
AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQMDD DQFCKIQEKL AQLELENKEL
RELLSISSES LRVRKENSMD TASQAIK
//
