ID A0A2U3VCF0_ODORO Unreviewed; 1118 AA.
AC A0A2U3VCF0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transcriptional repressor NF-X1 isoform X2 {ECO:0000313|RefSeq:XP_004392244.1};
GN Name=NFX1 {ECO:0000313|RefSeq:XP_004392244.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004392244.1};
RN [1] {ECO:0000313|RefSeq:XP_004392244.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR RefSeq; XP_004392244.1; XM_004392187.1.
DR AlphaFoldDB; A0A2U3VCF0; -.
DR GeneID; 101363749; -.
DR KEGG; oro:101363749; -.
DR CTD; 4799; -.
DR OrthoDB; 1412at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 6.
DR CDD; cd02643; R3H_NF-X1; 1.
DR CDD; cd16696; RING-CH-C4HC3_NFX1; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034076; R3H_NF-X1.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00438; ZnF_NFX; 9.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 353..409
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 356..407
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 992..1060
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 22..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 124177 MW; 1F4812ACE6CCDF85 CRC64;
MAEAPPVSGT FKFNTDAAEF IPQERKNSGL NCGSQRRLDS NRIDRRNYSS PPPCHLSRQV
PYDDISAVHQ HSYPLGSKPK SQQISFQSSA SNKSLKSHGL QNQPWQKLRS EKQHIKVKKV
QNLTDQTSDA PGLESVARSE SGTNPREHSP SENEKEIVGA DPRGAKPKKA AQFVYSYGRG
PKVKGKLKCE WGNRMTPKSE DAGPENTKPV GVIHPDSSDT SFKKGVLDGY AARRNEQRRY
PQKRPPWEVE GARPRPGRNP PKQEGQRPTN VGPRNNMAPI PKDNPNERPA KSACDNGNLA
VVNKSSRRVD PEKCAVRRQD PLVTSFPRGK QNHVLKNVET HTGSLIEQLT TEKYECMVCC
ELVRVTAPVW SCQSCYHVFH LNCIKKWARS PASQADGQSG WRCPACQNVS AHVPNTYTCF
CGKVKNPEWS RNEIPHSCGE VCRKKQPGQD CPHSCNLLCH PGPCPPCPAF MTKTCECGRT
RHTVRCGQAV SVHCSNPCEN LLNCGQHHCA ELCHGGQCQP CRIILNQVCY CGSTSRDVLC
GTDTGKSDGF GDFGCLKICG KDLKCGNHTC SQVCHPQPCQ PCPRLPQLLR CCPCGQTPLT
QLLELGSNGR KTCMDPVPSC GKVCGKPLSC GSLDFIHTCE KLCHEGDCGP CSRTSVISCR
CSFRTKELPC TSLKSEDATF MCDKRCNKKR LCGRHKCNEI CCVDKEHKCP LICGRKLRCG
LHRCEEPCHR GNCQSCWQAS FDELTCHCGA SVIYPPVPCG TRPPECTQTC ARVHECDHPV
YHSCHSEEKC PPCTFLTQKW CMGRHELRSN IPCHLADISC GLPCSATLPC GMHKCQRLCH
KGECLVDEAC KQPCTTLRAD CGHPCMAPCH PSSPCPMTAC KAKIELQCEC GRRKEMMICS
EASSTYQRIA AISMASKITD MQLGDSVEIS KLITKKEIHQ ARLECDEECL ALERKKRLAE
AFHISEDSDP FNVRSSGSKF SDSLKDDARK DIKFVSDIEK EMEALVEAVN KGKNSKKSHC
FPPMNRDHRR IIHDLAQVYG LESVSYDSEP KRNVVVTAVR GRSICPPSTL TCVLEREMQS
RPPPPIPHHR HQTDKNPASS NLQKIAKEPV IDYFDVQD
//
