ID A0A2U3VEP8_ODORO Unreviewed; 714 AA.
AC A0A2U3VEP8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Propionate--CoA ligase {ECO:0000256|ARBA:ARBA00029726};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.17 {ECO:0000256|ARBA:ARBA00012985};
GN Name=ACSS2 {ECO:0000313|RefSeq:XP_004393143.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004393143.1};
RN [1] {ECO:0000313|RefSeq:XP_004393143.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA;
CC Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392,
CC ChEBI:CHEBI:456215; EC=6.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR RefSeq; XP_004393143.1; XM_004393086.1.
DR AlphaFoldDB; A0A2U3VEP8; -.
DR STRING; 9708.A0A2U3VEP8; -.
DR GeneID; 101373113; -.
DR KEGG; oro:101373113; -.
DR CTD; 55902; -.
DR InParanoid; A0A2U3VEP8; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF126; ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT DOMAIN 47..107
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 116..541
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 596..674
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80748 MW; 06D518E2AD97046D CRC64;
MGLPEERGRS GSRSAEREEA GARNRVRSWS PPPKVSRSAH VRSLQRYREL HRRSVEQPRE
FWGDIAKEFY WKTSCPGPFL RYNFDVTKGK IFIEWMKGAT TNICYNVLDR IVHEKKLGDK
VAFYWEGNEP EETTQITYRE LLVQVCRFSN VLQKQGIRKG DRVAIYMPMI PELVVAMLAC
ARLGALHSIV FAGFSAESLC ERILDSSCSL LITTDAFYRG EKLVNLKELA DEALEKCREK
AFQVRCCIVV KHLGRAELGT GDSPSQSPPI KRPCPDVQGK LREKPKRIWP QISWNQGVDL
WWHELMQEAE DECEPEWCDA EDPLFILYTS GSTGKPKGVV HTLGGYMLYV ATTFKYVFDF
HAEDVFWCTA DIGWITGHSY VTYGPLANGA TSVLFEGIPT YPDVSRLWNI VDKYKVTKFY
TAPTAIRLLM KFGNEPVTRH SRASLQVLGT VGEPINPEAW LWYHQVVGAQ RCSIVDTFWQ
TETGGHMLTP LPGATPMKPG SATFPFFGVA PAILNESGEE LEGEAEGYLV FKQPWPGIMR
TVYGNHERFE ATYFKKFPGY YVTGDGCRRD QDGYYWITGR IDDMLNVSGH LLSTAEVESA
LVEHEAIAEA AVVGHPHPVK GECLYCFVTL CDGYTFSPTL TEELKKQIRE KIGPIATPDY
IQNAPGLPKT RSGKIMRRVL RKIAQNDHDL GDMSTVADPT VICQLFNHRC LTSQ
//