ID   A0A2U3VFI2_ODORO        Unreviewed;       244 AA.
AC   A0A2U3VFI2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Thymidine kinase 2, mitochondrial isoform X2 {ECO:0000313|RefSeq:XP_004393483.1};
GN   Name=TK2 {ECO:0000313|RefSeq:XP_004393483.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004393483.1};
RN   [1] {ECO:0000313|RefSeq:XP_004393483.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
CC       {ECO:0000256|ARBA:ARBA00007420}.
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DR   RefSeq; XP_004393483.1; XM_004393426.1.
DR   AlphaFoldDB; A0A2U3VFI2; -.
DR   GeneID; 101375517; -.
DR   KEGG; oro:101375517; -.
DR   CTD; 7084; -.
DR   OrthoDB; 5393913at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01673; dNK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_004393483.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          50..240
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   REGION          14..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        112
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         54..62
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         171..175
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ   SEQUENCE   244 AA;  28476 MW;  CA3006E33AB3D770 CRC64;
     MLRRPLRTWA ARALRREGPG NPAPGRGTRG IQRRAWPRDR ENEKEKKSVI CVEGNIASGK
     TTCLEFFSNT AGIEGLMYRD ACRWGLTLQT YVQLTMLDHH TRPQASPVRL MERSIHSARY
     IFVENLYRSG KMPEVDYVIL SEWFDWIVRN IDVSVDLIVY LRTTPETCYQ RLRLRCREEE
     TVIPLDYLNA IHHLYEEWLI QGGLFPVAAP VLVIEADHDV QKMLKLFEQN RDRILTPENQ
     KHGS
//