ID A0A2U3VGU3_ODORO Unreviewed; 1251 AA.
AC A0A2U3VGU3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 3 isoform X2 {ECO:0000313|RefSeq:XP_004394001.1};
GN Name=LTBP3 {ECO:0000313|RefSeq:XP_004394001.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004394001.1};
RN [1] {ECO:0000313|RefSeq:XP_004394001.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_004394001.1; XM_004393944.2.
DR AlphaFoldDB; A0A2U3VGU3; -.
DR GeneID; 101383632; -.
DR CTD; 4054; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 10.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 9.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 13.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1251
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015526775"
FT DOMAIN 104..136
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 272..315
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 350..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 398..450
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 569..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 611..648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 655..697
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 739..779
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 780..820
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 821..860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 861..903
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 912..966
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1031..1071
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1084..1129
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT REGION 241..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 108..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 126..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1251 AA; 133571 MW; EBAB065D392FC599 CRC64;
MPGPRGAAGC LAPEMRGAGT AGLLALLLLL GPGGGAEGGP AGERGAGGGG ALARERFKVV
FAPVICKRTC LKGQCRDSCQ QGSNMTLIGE NGHSTDTLTG SGFRVVVCPL PCMNGGQCSS
RNQCLCPPDF TGRFCQVPAG GAGGGTGGSG PGLGRAGALS TGALPPLAPE SESVASKHAI
YAVQVIADPP GPGEGPPAQH AAFLVPLGPG QISAEVQAPP PVVNVRVHHP PEASVQVHRI
EGPNAEGPAP SQHLLPHPKP QHPRPPTQKP LGRCFQDTLP KQPCGSNPLP GLTKQEDCCG
SIGTAWGQSK CHKCPQLQYT GVQKPGPVRG EVGADCPQGY KRLNSTHCQD INECAMPGMC
RHGDCLNNPG SYRCVCPPGH SLGPSRTQCI ADKPEEKSLC FRLVSPEHQC QHPLTTRLSR
QLCCCSVGKA WGARCQRCPA DGTAAFKEIC PAGKGYHILT SHQTLTIQGE SDFSLFLHPD
GPPKPQQPPE SPSRAPPPED TEEERGVSTD SPVIEEQSAQ QSHPIATTSP ARPYPELISR
PSPPTVRWFL PDLPPSRSAV EIAPTQVTET DECRLNQNIC GHGECVPGPS DYSCHCNPGY
RSHPQHRYCV DVNECEAEPC GAGRGVCMNT GGSYNCHCHR GYRLHVGAGG RSCVDLNECA
KPHLCGDGGF CLNFPGHYKC NCYPGYRLKA SRPPVCEDID ECRDPSSCPD GKCENKPGSF
KCIACQPGYR SHGGGACRDV NECAEGSPCS PGWCENLPGS FRCTCAQGYA PAPDGRSCQD
VDECEAGDVC DNGICTNTPG SFQCQCLSGY HLSRDRSRCE DIDECDFPAA CIGGDCINTN
GSYRCLCPQG HRLVGGRKCQ DIDECSQDPG LCLPHGACEN LQGSYACVCD EGFTPTQDQH
GCEEVEQPHH KKECYLNFDD TVFCDSVLAT NVTQQECCCS LGAGWGDHCE IYPCPVYSSA
EFHSLCPDGK GYTQDNNIVN YGIPAHRDID ECILFGAEIC KEGKCVNTQP GYECYCKQGF
YYDGNLLECV DVDECLDESN CRNGVCENTR GGYRCACTPP AEYSPAERQC LSPEEMERAP
ERRDVCWAQR GEDGMCAGPL TGPTLTFDDC CCRQGRGWGA QCRPCPPRSA GSQCPTSQSE
SNSFWDASPL LLGKPPREED SSEEDSDECR CVSGRCVPRP GGAVCECPGG FQLDASRARC
VDIDECRELN QRGLLCKSER CVNTSGSFRC VCKAGFARSR PHGACVPQRR R
//
