ID   A0A2U3VIE5_ODORO        Unreviewed;      1287 AA.
AC   A0A2U3VIE5;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=DENN domain-containing protein 5A isoform X1 {ECO:0000313|RefSeq:XP_004394621.1};
GN   Name=DENND5A {ECO:0000313|RefSeq:XP_004394621.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004394621.1};
RN   [1] {ECO:0000313|RefSeq:XP_004394621.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC       {ECO:0000256|ARBA:ARBA00006664}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   RefSeq; XP_004394621.1; XM_004394564.1.
DR   STRING; 9708.A0A2U3VIE5; -.
DR   GeneID; 101384020; -.
DR   KEGG; oro:101384020; -.
DR   CTD; 23258; -.
DR   InParanoid; A0A2U3VIE5; -.
DR   OrthoDB; 5398783at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   CDD; cd01757; PLAT_RAB6IP1; 1.
DR   CDD; cd17690; RUN1_DENND5A; 1.
DR   CDD; cd17692; RUN2_DENND5A; 1.
DR   Gene3D; 1.20.58.900; -; 2.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR047278; DEN5A/B.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR047277; PLAT_RAB6IP1.
DR   InterPro; IPR047294; RUN1_DENND5A.
DR   InterPro; IPR047295; RUN2_DENND5A.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR   PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02759; RUN; 2.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00593; RUN; 2.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF140741; RUN domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS50826; RUN; 2.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          57..598
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          787..950
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          954..1062
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   DOMAIN          1134..1282
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          681..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1287 AA;  146901 MW;  07BDB769043C7E71 CRC64;
     MSGGGGGGGS APSRFADYFV ICGLDTETGL EPDELSALCQ YIQASKARDG ASPFISSTTE
     GENFEQTPLR RTFKSKVLAR YPENVEWNPF DQDAVGMLCM PKGLAFKTQA DPREPQFHAF
     IITREDGSRT FGFALTFYEE VTSKQICSAM QTLYHMHNAE YDVLHSPSVD GRDHSGMEDG
     EGTPGTKLQR FNSYDISRDT LYVSKCICLI TPMSFMKACR SVLEQLHQAV TSPQPPPLPL
     ESYIYNVLYE VPLPPPGRSL KFSGVYGPII CQRPSTNELP LFDFPVKEVF ELLGVENVFQ
     LFTCALLEFQ ILLYSQHYQR LMTVAETITA LMFPFQWQHV YVPILPASLL HFLDAPVPYL
     MGLHSNGLDD RSKLELPQEA NLCFVDIDNH FIELPEDLPQ FPNKLEFVQE VSEILMAFGI
     PPEGNLHCSE SASKLKRLRA SELVSDKRNG NIAGSPLHSY ELLKENETIA RLQALVKRTG
     VSLEKLEVRE DPSSNKDLKV QCDEEELRIY QLNIQIREVF ANRFTQMFAD YEVFVIQPSQ
     DKESWFTNRE QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDDDDKDPV
     LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TVDEAEKAIE LRLAKIDHTA IHPHLLDMKI
     GQGKYEPGFF PKLQSDVLST GPASNKWTKR NAPAQWRRKD RQKQHTEHLR LDNDQREKYI
     QEARNMGSTI RQPKLSNLSP SVIAQTNWKF VEGLLKECRN KTKRMLVEKM GREAVELGHG
     EVNITGVEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH LLHYQENRQR KLTSGSLSTS
     GILLDSERRK SDASSVMSPL RISLIQDMRH IQNIGEIKTD VGKARAWVRL SMEKKLLSRH
     LKQLLSDHEL TKKLYKRYAF LRCDDEKEQF LYHLLSFNAV DYFCFTNVFT TILIPYHILI
     VPSKKLGGSM FTANPWICIS GELGETQILQ IPRNVLEMTF ECQNLGKLTT VQIGHDNSGL
     YAKWLVEYVM VRNEITGHTY KFPCGRWLGK GIDDGSLERV LVGELLTSQP EVDERPCRTP
     PLQQSPSVIR RLVTISPNNK PKLNTGQIQE SIGEAVNGIV KHFHKPEKER GSLTLLLCGE
     CGLVSALEQA FQHGFKSPRL FKNVFIWDFL EKAQTYFETL EQNELVPEEN WHTRARNFCR
     FVTAINNTPR NIGKDGKFQM LVCLGARDHL LHHWIALLAD CPITAHMYED VALIKDHTLV
     NSLIRVLQTL QEFNITLETS LVKGIDI
//