ID A0A2U3VIS5_ODORO Unreviewed; 714 AA.
AC A0A2U3VIS5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Connector enhancer of kinase suppressor of ras 1 isoform X1 {ECO:0000313|RefSeq:XP_004394767.1};
GN Name=CNKSR1 {ECO:0000313|RefSeq:XP_004394767.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004394767.1};
RN [1] {ECO:0000313|RefSeq:XP_004394767.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR RefSeq; XP_004394767.1; XM_004394710.2.
DR AlphaFoldDB; A0A2U3VIS5; -.
DR GeneID; 101377461; -.
DR KEGG; oro:101377461; -.
DR CTD; 10256; -.
DR OrthoDB; 5406576at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF10; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:XP_004394767.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Transferase {ECO:0000313|RefSeq:XP_004394767.1}.
FT DOMAIN 7..70
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 78..164
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 196..278
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 397..496
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 278..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..295
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 78971 MW; E4C9B8C51416E421 CRC64;
MEPVATWTPG KVAAWLRGLD DSLQDYCFED WELSGKYLLQ LCPRSLEALT VWPVGHQELI
LEGVEQLRAL SSGLQTENLQ SLTEGLLEGT YAFQSLVQGH LEGCAEPPAD VLSAAVELVH
EARTLLFWLN RYLFSHLNDF SACQKIGELC GELGQALQED SPAAEKESRV LGICSHVARI
CHHILSCSPQ ELLEQRAVLE RVQLDHPLGL EVHTTSNCLH FVSRVGTQVP ADSQLQILPG
DEIVQVNEQV VVGWPHKNVV RELLREPAGV SLVLKKVPVP KTPPQTPPPV PGSPQLTSPS
LAFTLLSPRA SSKDVFAFDP TSNPSPAPSP TWTDSTSLDL ESRPILPAPP ATLPAGVAEA
REGPEQPDKS PVSGRNKSKG VATRLSRRRV SCRELGQPDC DGWLLLRKAP GGFMGPRWRR
CWFVLKRHTL YWYRQPQDEK AEGLINVSNY SLESGQDQKK KYVFQLTHDV YKPFIFAADT
LEDLSLWVRH LITCISKYQS PGQASLPREE DCYSETEAED PDDEAGSRSA SPSPAQVWSP
LHGDTSPTAT PMQGSPRTSF GPPTDTSEGA LEGMVQGLRQ GGVSLLGQPQ PLTHEQWRSS
FMRRNRDPQL NERVHRVRAL QSTLKAKLQE LQALEEVLGD PELTGEKFRQ WKEQNQELYS
EGLGGWGVVQ AEGHSQVLSS DSREQSSHPL PSDPEEQSCL CPLTPESNLR PSDL
//
