ID A0A2U3VLL4_ODORO Unreviewed; 1179 AA.
AC A0A2U3VLL4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fibulin-2 isoform X2 {ECO:0000313|RefSeq:XP_004395736.1};
GN Name=FBLN2 {ECO:0000313|RefSeq:XP_004395736.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004395736.1};
RN [1] {ECO:0000313|RefSeq:XP_004395736.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_004395736.1; XM_004395679.2.
DR AlphaFoldDB; A0A2U3VLL4; -.
DR GeneID; 101382007; -.
DR CTD; 2199; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF01821; ANATO; 2.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF14670; FXa_inhibition; 1.
DR SMART; SM00104; ANATO; 3.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1179
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015700151"
FT DOMAIN 440..475
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 483..514
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 516..548
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 599..640
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 853..891
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 896..937
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 938..976
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 256..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 125653 MW; FF4319E014AA5A53 CRC64;
MARLREPAGA LLALALALGL HAGTAAPRQD CTGVECAPLE NCIEEALEPG ACCATCVQQG
CACEGYQYYD CLQGGFVRGR VPAGQSYFVD FGSTECSCPP GGGKISCQFM LCPELPPNCI
EAVVAADSCP QCGQVGCVHT GRKYAAGHTV HLPPCRACHC PDAGGELICY QLPGCRGDAE
AVPAAAAGNF SDAEEGDSER HYEDPYSYDQ EVAEAEAAAA LAGELQAGAG GPAALGGGSQ
LSSAIQATPW PAALPRPTAA AALGPPAPVQ AKARRVTEDS QGEGQEETEE LATREQPAAG
GPRGLDGSPT PGPTGPALPA QEDKAEARAG PEENLIPEAR ATLHSAGQEG AGHVLGSSST
SVPPSQATPS SPGGTMKPNT HTILTLSPQE AAWVPPTQEV PKQPPVLPRS RPEEETDPNS
VHSVPRGDPE VSTKDLIETC CAAGQQWAID NDECLEIPES GAEGDACRTA QKHCCVSYLK
EKSCMAGVMG AKEGEACGPE DNDTCGVSLY KQCCDCCGLG LRVRAEGHSC ESNPNLGYPC
NHVMLSCCEG EDPLIVPEVR RPPEPEAVPR RVAEAELASR EALSLGTETE LPNSLPGDDQ
DECLLLPGEL CQHLCINTVG SYHCACFPGF SLQDDGRTCR PDGDPPQPEA AEESALKPDS
SQVASNTIVL PVPQPNTCKD NGPCKQVCSV VGDTAMCSCF PGYAIMADGV SCEDINECVT
DLHSCSRGEH CMNTVGSFHC YKALTCEPGY ALKDGECADV NECELGTHNC QAGFTCQNTK
GSFYCQARQR CMEGFLQDPE GNCVDINECT SLAEPCRPGF SCINTVGSYT CQRNPLLCGR
GYHANQDGTK CVDVNECETG VHQCGEGQVC HNLPGSYRCD CKPGFQRDAF GRACVDVNEC
WTSPGRLCQH TCENTLGSYR CSCATGFLLA ADGKRCEDVN ECEAQRCSQE CTNIYGSYQC
YCRQGYQLAE DGHTCTDIDE CAQGASILCT FRCVNVPGSY QCACPERGYT MTANGRSCKD
LDECALGTHN CSETETCHNI RGGFRCLRFE CPPNYVRVSE TKCERTTCHD FMECQNSPAR
ITYYQLNFQT GLLVPAHIFR ISPVPVFAGD TISLTITKGN EEGYFGTRPL NAYTGVVYLQ
RLVREPRDFA LDVEMKLWRQ GSVTTFLAKM HIFFTTFAL
//
