ID A0A2U3VNR7_ODORO Unreviewed; 748 AA.
AC A0A2U3VNR7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transducin-like enhancer protein 4 isoform X8 {ECO:0000313|RefSeq:XP_004396764.1};
GN Name=TLE4 {ECO:0000313|RefSeq:XP_004396764.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004396764.1};
RN [1] {ECO:0000313|RefSeq:XP_004396764.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004396764.1; XM_004396707.2.
DR AlphaFoldDB; A0A2U3VNR7; -.
DR GeneID; 101381815; -.
DR CTD; 7091; -.
DR OrthoDB; 1333122at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 24..110
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 548..589
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 590..631
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 672..703
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..59
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 157..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 81041 MW; DF15A6C2A13C1079 CRC64;
MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEQQLQA QHLSHGHGLP
VPLTPHPSGL QPPAIPPIGS SAGLLALSSA LGGQSHLPIK DEKKHHDNDH QRDRDSIKSS
SVSPSASFRG AEKHRNSTDY SSDSKKQKTE EKEIAARYDS DGEKSDDNLV VDVSNEDPSS
PRGSPAHSPR ENGLDKTRLL KKDAPISPAS IASSSSTPSS KSKELSLNEK STTPVSKSNT
PTPRTDAPTP GSNSTPGLRP VPGKPPGVDP LASSLRTPMA VPCPYPTPFG IVPHAGMNGE
LTSPGAAYAG LHNISPQMSA AAAAAAAAAA YGRSPVVGFD PHHHMRVPAI PPNLTGIPGG
KPAYSFHVTA DGQMQPVPFP PDALIGPGIP RHARQINTLN HGEVVCAVTI SNPTRHVYTG
GKGCVKVWDI SHPGNKSPVS QLDCLNRDNY IRSCRLLPDG RTLIVGGEAS TLSIWDLAAP
TPRIKAELTS SAPACYALAI SPDSKVCFSC CSDGNIAVWD LHNQTLVRQF QGHTDGASCI
DISNDGTKLW TGGLDNTVRS WDLREGRQLQ QHDFTSQIFS LGYCPTGEWL AVGMENSNVE
VLHVTKPDKY QLHLHESCVL SLKFAHCGKW FVSTGKDNLL NAWRTPYGAS IFQSKESSSV
LSCDISVDDK YIVTGSGDKK ATVYEVIY
//
