ID A0A2U3VPK2_ODORO Unreviewed; 3441 AA.
AC A0A2U3VPK2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Utrophin isoform X1 {ECO:0000313|RefSeq:XP_004397096.1};
GN Name=UTRN {ECO:0000313|RefSeq:XP_004397096.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004397096.1};
RN [1] {ECO:0000313|RefSeq:XP_004397096.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR002341}.
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DR RefSeq; XP_004397096.1; XM_004397039.2.
DR STRING; 9708.A0A2U3VPK2; -.
DR GeneID; 101366169; -.
DR KEGG; oro:101366169; -.
DR CTD; 7402; -.
DR InParanoid; A0A2U3VPK2; -.
DR OrthoDB; 2880153at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd21232; CH_UTRN_rpt1; 1.
DR CDD; cd21234; CH_UTRN_rpt2; 1.
DR CDD; cd16247; EFh_UTRO; 1.
DR CDD; cd00176; SPEC; 11.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035436; Dystrophin/utrophin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR PANTHER; PTHR12268:SF26; UTROPHIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 9.
DR Pfam; PF00569; ZZ; 1.
DR PIRSF; PIRSF002341; Dystrophin/utrophin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 19.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 14.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002341}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR002341}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002341};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002341};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002341};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|PIRNR:PIRNR002341};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|PIRNR:PIRNR002341};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 31..135
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..255
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2811..2844
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 3064..3120
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3356..3376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1098..1187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2114..2141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2685..2712
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3252..3286
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1395..1410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3441 AA; 395216 MW; B4674131FCF5F22C CRC64;
MAKYGEHEAR PDDGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK PPINDMFTDL
KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL HQNNVDLVNI GGTDIVDGNH
KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT NSEKILLSWV RQSTRPYSQV NVLNFTTSWT
DGLAFNAVLH QHKPDLFSWD RVVKMSPIER LEHAFGKAQT YLGIEKLLDP EDVAVQLPDK
KSIIMYLTSL FEVLPQQVTL DAIREVETLP RKYKKECEEG EISLQSSVLE EEHESPGAET
PSTVAEVDMD LDSYQIALEE VLTWLLSAED TFQEQEDIAD DVEEVKDQFA THEAFMMELT
AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR WEALRVDSMD RQSRLHDVLM
ELQKRQLEQL SAWLMLTEER IQKMETRPLD DDLKSLQKLL EDHKCLQNDL EAEQVKVNSL
THMVVIVDEN SGESTTALLE DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL
LKAWLTEKEE ALNKVQTSNF KDQKELSVSI RRLAILKEDM EMKRQALDQL SEIGQDVGQL
LDNPKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK ALLETVRVRE
QVTTKRSKQE LPPPPPKKRQ IPVDTEAKKK FDAVSAELLN YILKSKTAIQ ATEIKGYKKM
QETSEMKKKL KGFEKEQTER SPRLDELNQT GQILLEQMGK EGIPMEEIKN VLEKVFSEWK
DVSQRLEDLA RKIQLQEDIN AYFKQLDDLE KTIKAKEEWV KHTPFLESPQ QPLPSLKDSC
QRELADLLSL HPRIERAHAG CSALRSRPSA PDFVRQAFES LLGRYQAVRQ DLEHHQQQLE
NELKSQPGHA YLETLKTLKE TLNDSESKAQ TSLNALNDLP KVAKALQERK ALDEILENQK
PTLYKLAEET KSLEKNVSPD VEKMYKQEFD DVQGKWNKLK VKVSKDLHLL EEITSRLKAF
EADLKVIEKW MDGVKDFLMK EQVVQGDAEG LQSQLDQCSA FVNEIETVES SLKDMKEIEA
NLRSCPVAGI KTWMQTKLVD YQTQSEKLSK EIAIQKNRLS ESQEKAVNLK KDLSEMQEWM
TQAEEEYLER DFEYKSPEEL ESAVEEMKRA KEDVLQKEVR VKILKDNIML LAAKAPSGGQ
ELTSELNVVL ENYQLLCNRI RGKCHTLEEV WSCWIELLHY LDLETCWLST LEERMKSTEA
LPEKSDAVNE ALESLESVLR HPADNRTQIR ELGQTLIDGG ILDDIISEKL EAFNSRYEDL
SHLAESKQIA LEKQLQVLRE TDHMLQVLQE SLGELDKQLT TYLTDRIDAF QVPQEAQKIQ
AEISAHELTL EELRRNTRSQ PPTSPEGRNA RGGSQMDLLQ RKLREVSTKF QLFQKPANFE
QRMLDCKRVL DCVKAELHVL DVKDVDPDVI QSHLDKCMKL YKTLSEVKLE VETVIKTGRH
IVQKQQTDNP RGMDEQLTSL KILYNDLGAQ VTEGKQDLER ASQLARKMKK ETASLSEWLS
VTEAELVQKS TSEGLLGDLD IEISWAKNIL KDLEKRKADL NTITESSAAL KNLIEGSEPV
LEERLCVLNA GWSRVRTWTE DWCNTLMNHQ NQLEIFDGNV AHISTWLYQA EALLDEIEKK
PASKREEIVK RLISELDDAN LQVENVRDQA IVLMNARGGS SRELVEPKLA ELNRNFEKVS
QHIRSAKLLI GQEPLAYQCL VTTEAFEADV LFSDLEKLES GIENMLKVVE KHLEFSDEDE
KMDEERAQIE EVLQRGEQML HQPMEDNKKE KIRLQLLLLR TRYNKTKAVP NQQTTGQLAP
GTRSPPLPTD YLVEINKVLL SVDDAELSLN APELSTVVYE DFSFQEDSLK NIKDQLDKLG
EQIAVIHEKQ PDVILEASGP EAIQIRDILT QLNGKWDRIN RMYNDRKGHF DRAMEEWRQF
HCDLNDLTQW ITEAEELLAE TLAPDGSLDL EKAGMYQQEL EEGISSHQPS FAALNRTGDG
IVQKLSPMDG SFLKDKLAGL NQRWSAIFAE VKDRRPRLKG ESKQVMDYRK RLDDIICWLT
KAENALQKRS TTELEENLQE LTDLTQEMDV QAEKLKWLNR NELEMLSDKS LSLHEREKIS
ESLRTVNSTW NKICREVPST LKERIQEPCS VSQTRIAAHP GVQKVVLVSS ASDIPAQSPR
TSEISVPADL DKTITELADW LVLIDQMLKS NIVTVGDIEE INKTVSRMKI TKADLEQRHP
QLDYVFTLAQ NLKNKASSSD VRTAITEKLE KVKNQWDSTQ HGVELRQQQL EDMIIDSLQW
DDHREETEEL MRKYEARLYI LQQARRDPLI KQISDNQILL QELGPGDGIV MAFDNVLQKL
LEDYGSDDTR NVKETTEYLK TSWINLKQSI ADRQSALEAE LRTVQASRRD LENFLKWIQE
AETTVNVLAD ASQRENVLQD TVLARELTRQ LQDIQAEIDA HNDIFKSIDG NRQKMVKALG
NSEEATMLQH RLDDMNQRWN DLKAKSASIR AHLEASAEKW NRLLTSLEEL IKWLNVKDEE
LQKQMPIGGD VPALQLQYDH CKALRRELKE KEYSVLNAID QARVFLADQP IEAPEEPRRN
LQSKTELTPE ERAQKIAKAM RKQSSEVKEK WESLNAVTSN WQKQVDKALE KLRDLQGSMD
DLDVDMKEAE AVRNGWKPVG DLLIDSLQDH IEKTMAFREE IAPINLKVKT VNDLSSQLSP
LDLHPSLKMS RQLDDLNMRW KLLQVSVDDR LKQLQEAHRD FGPSSQHFLS TSVQLPWQRS
ISHNKVPYYI NHQTQTTCWD HPKMTELFQT LADLNNVRFS AYRTAIKIRR LQKALCLDLL
ELNTTNEVFK QHKLNQNDQL LSVPDVINCL TTTYDGLEQM HKDLVNVPLC VDMCLNWLLN
VYDTGRTGKI RVQSLKIGLM SLSKGLLEEK YRYLFKEVAG PTEMCDQRQL GLLLHDAIQI
PRQLGEVAAF GGSNIEPSVR SCFQQNNNKP EISVKEFIDW MRLEPQSMVW LPVLHRVAAA
ETAKHQAKCN ICKECPIVGF RYRSLKHFNY DVCQSCFFSG RTAKGHKLHY PMVEYCIPTT
SGEDVRDFTK VLKNKFRSKK YFAKHPRLGY LPVQTVLEGD NLETPVTLIS MWPEHYDPSQ
SPQLFHDDTH SRIEQYATRL AQMERTNGSF LTDSSSTTGS VEDEHALIQQ YCQTLGGESP
VSQPQSPAQI LKSVEREERG ELERIIADLE EEQRSLQVEY EQLKEQHLRR GFPVGSPPDS
VVSPHHTSED SELIAEAKLL RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPESDSR
INGVSPWASP QQSALSYSLD PDPGPQFHQA AAEDLLSPPH DTGTELTEFM EQITSTFPSC
CPNLPSRPQV RVNGVDWLRD C
//
