ID A0A2U3VSG4_ODORO Unreviewed; 804 AA.
AC A0A2U3VSG4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase alpha {ECO:0000256|PIRNR:PIRNR002006};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR002006};
GN Name=PTPRA {ECO:0000313|RefSeq:XP_004398215.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004398215.1};
RN [1] {ECO:0000313|RefSeq:XP_004398215.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR002006};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765,
CC ECO:0000256|PIRNR:PIRNR002006}.
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DR RefSeq; XP_004398215.1; XM_004398158.2.
DR AlphaFoldDB; A0A2U3VSG4; -.
DR GeneID; 101384039; -.
DR CTD; 5786; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14621; R-PTPc-A-1; 1.
DR CDD; cd14623; R-PTPc-A-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR InterPro; IPR027262; Tyr_Pase_rcpt_alpha.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF433; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PIRSF; PIRSF500808; PTPR_alpha; 1.
DR PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR002006};
KW Membrane {ECO:0000256|PIRNR:PIRNR002006};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
KW Receptor {ECO:0000313|RefSeq:XP_004398215.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Signal {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR002006}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT CHAIN 31..804
FT /note="Receptor-type tyrosine-protein phosphatase alpha"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT /id="PRO_5016196459"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT DOMAIN 243..503
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 423..494
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 535..793
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 709..784
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 47..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 444
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT ACT_SITE 734
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT BINDING 412
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 444..450
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 488
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT MOD_RES 800
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ SEQUENCE 804 AA; 90756 MW; 6CA72E4199732717 CRC64;
MDDAVQVTKV SMDSWFILVL LGSSLTRVGA NNGTTVSPSV GITRSMKTST AESVKEETKA
SNTISSVTSP SVAPTFSPNL TLGPTYVTTV NASDSDNGTT RTASTGSVVT TLAPNGTWLP
ENQFTDTSTE PWEGNSSTVA TTPETFPPSD ETPIIAVMVA LSSLLVIVFI IIVLYMLRFK
KYKQAGSHSN SFRLSNGRTE DVEPQSVPLL ARSPSTNRKY PPLPVDKLEE EINRRMADDN
KLFREEFNAL PACPIQATCE AASKEENKEK NRYVNILPYD HSRVHLTPVE GVPDSDYINA
SFINGYQEKN KFIAAQGPKE ETVNDFWRMI WEQNTATIVM VTNLKERKEC KCAQYWPDQG
CWTYGNIRVS VEDVTVLVDY TVRKFCIQQV GDVTNRKPQR LITQFHFTSW PDFGVPFTPI
GMLKFLKKVK ACNPQYAGAI VVHCSAGVGR TGTFVVIDAM LDMMHTERKV DVYGFVSRIR
AQRCQMVQTD MQYVFIYQAL LEHYLYGDTE LEVTSLETHL QKIYNKIPGT SNNGLEEEFK
KLTSIKIQND KMRTGNLPAN MKKNRVLQII PYEFNRVIIP VKRGEENTDY VNASFIDGYR
QKDSYIASQG PLLHTIEDFW RMIWEWKSCS IVMLTELEER GQEKCAQYWP SDGVVSYGDI
TVELKKEEEC ESYTVRDLLV TNTRENKGRQ IRQFHFHGWP EVGIPSDGKG MISIIAAVQK
QQQQSGNHPI TVHCSAGAGR TGTFCALSTV LERVKAEGIL DVFQTVKSLR LQRPHMVQTL
EQYEFCYKVV QEYIDAFSDY ANFK
//
