ID A0A2U3VSM2_ODORO Unreviewed; 493 AA.
AC A0A2U3VSM2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Major centromere autoantigen B {ECO:0000313|RefSeq:XP_004398282.1};
GN Name=CENPB {ECO:0000313|RefSeq:XP_004398282.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004398282.1};
RN [1] {ECO:0000313|RefSeq:XP_004398282.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
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DR RefSeq; XP_004398282.1; XM_004398225.2.
DR AlphaFoldDB; A0A2U3VSM2; -.
DR STRING; 9708.A0A2U3VSM2; -.
DR GeneID; 101379502; -.
DR KEGG; oro:101379502; -.
DR CTD; 1059; -.
DR InParanoid; A0A2U3VSM2; -.
DR OrthoDB; 2382272at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.1090; Dimerisation domain of CENP-B; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR015115; CenpB_C.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR034882; Dimerisation_CENP-B_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR19303:SF72; MAJOR CENTROMERE AUTOANTIGEN B; 1.
DR PANTHER; PTHR19303; TRANSPOSON; 1.
DR Pfam; PF09026; CENP-B_dimeris; 1.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF101160; Dimerisation domain of CENP-B; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DOMAIN 65..136
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000259|PROSITE:PS51253"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 144..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..365
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..434
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 53897 MW; D93D20A3ACDEB293 CRC64;
MGPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG
VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN
GWLDRFRRRH GVVSCSGVAR ARSRNAAPRP AAAPASPPAV PSEGSGGGST GWRAREEQPP
SVAEGYASQD VFSAIETSLW YDFLPDQAAG LCGSDGRARR ATQRLSVLLC ANADGSEKLP
PLVAGKSAKP RAGQAGLPCD YTANSKGGVT TQALAKYLKA LDTRMAAESR RVLLLAGRLA
AQSLDTSGLR HVQLAFFPPG TAQKAWTILL GEELGEEEEV EEEGDVDDSE EEEEEEEEES
SSEGLEAEDW AQGVVEAGGS FGGYSAQEEA QCPTLHFLEG AEDSESDSEE EEEEEEDEDD
EDDEDEEEDG DEVPVPSFGE AMAYFAMVKR YLTSFPIDDR VQSHILHLEH DLVHVTRKNH
ARQAGVRGLG HQS
//
