ID A0A2U3VWB0_ODORO Unreviewed; 631 AA.
AC A0A2U3VWB0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A4 {ECO:0000313|RefSeq:XP_004399759.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004399759.1};
RN [1] {ECO:0000313|RefSeq:XP_004399759.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out)
CC + K(+)(out) + Na(+)(in) + serotonin(in); Xref=Rhea:RHEA:75839,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103,
CC ChEBI:CHEBI:350546; Evidence={ECO:0000256|ARBA:ARBA00035098};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75840;
CC Evidence={ECO:0000256|ARBA:ARBA00035098};
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004127}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A4 subfamily. {ECO:0000256|ARBA:ARBA00005461}.
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DR RefSeq; XP_004399759.1; XM_004399702.2.
DR AlphaFoldDB; A0A2U3VWB0; -.
DR STRING; 9708.A0A2U3VWB0; -.
DR GeneID; 101375365; -.
DR KEGG; oro:101375365; -.
DR CTD; 6532; -.
DR InParanoid; A0A2U3VWB0; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005335; F:serotonin:sodium:chloride symporter activity; IEA:InterPro.
DR CDD; cd11513; SLC6sbd_SERT; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR013086; Na/ntran_symport_serotonin_N.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF105; SODIUM-DEPENDENT SEROTONIN TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF03491; 5HT_transport_N; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01203; 5HTTRANSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU003732};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurotransmitter transport {ECO:0000256|ARBA:ARBA00022775};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 89..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..65
FT /note="Sodium:neurotransmitter symporter serotonin N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03491"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 70382 MW; 9B7C2EB7FC116F0D CRC64;
METTPLNSQK ELSACKDKED CQENGVLQKK GVPVPEDKVE SGHISNGYSA VPSPGAGDDS
QHSIPAATTA LVAEAHQGER ETWGKKMDFL LSVIGYAVDL GNVWRFPYIC YQNGGGAFLL
PYTIMAIFGG IPLFYMELAL GQYHRNGCIS IWRKICPIFK GIGYAICIIA FYIASYYNTI
MAWALYYLIS SFTDQLPWTS CTNSWNTGNC TNYFSGNNVT WTLHSTSPAE EFYTRHVLQI
HRSKGLQDLG GVSWQLTLCI MLIFTVIYFS IWKGVKTSGK VVWVTATFPY IILSVLLVRG
ATLPGAWRGV LFYLKPNWQK LLETGVWVDA AAQIFFSLGP GFGVLLAFAS YNKFNNNCYQ
DALVTSVLNC MTSFVSGFVI FTVLGYMAEM RNEDVSEVAK DAGPSLLFIT YAEAIANMPA
STFFAIIFFL MLITLGLDST FAGLEGVITA VLDEFPHIWT KRREWFVLGV VITCFFGSLA
TLTFGGAYVV KLLEEYATGP AVLTVVLIEA VAVYWFYGIT QFCSDVKEML GFSPGWFWRI
CWVAISPLFL LFIICSFLMS PPQLRLFQYN YPQWSIILGY CIGTSSFICI PTYIAYRLII
TPGTFKERII KGITPETATE IPYGDIHLNA I
//
