ID A0A2U3VWR1_ODORO Unreviewed; 265 AA.
AC A0A2U3VWR1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN Name=IL1A {ECO:0000313|RefSeq:XP_004399930.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004399930.1};
RN [1] {ECO:0000313|RefSeq:XP_004399930.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytokine constitutively present intracellularly in nearly all
CC resting non-hematopoietic cells that plays an important role in
CC inflammation and bridges the innate and adaptive immune systems. After
CC binding to its receptor IL1R1 together with its accessory protein
CC IL1RAP, forms the high affinity interleukin-1 receptor complex.
CC Signaling involves the recruitment of adapter molecules such as MYD88,
CC IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the
CC three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell,
CC acts as an alarmin and cell death results in its liberation in the
CC extracellular space after disruption of the cell membrane to induce
CC inflammation and alert the host to injury or damage. In addition to its
CC role as a danger signal, which occurs when the cytokine is passively
CC released by cell necrosis, directly senses DNA damage and acts as
CC signal for genotoxic stress without loss of cell integrity.
CC {ECO:0000256|ARBA:ARBA00034090}.
CC -!- SUBUNIT: Monomer. Interacts with TMED10; the interaction mediates the
CC translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-
CC Golgi intermediate compartment) and thereby secretion. Interacts with
CC IL1R1. Interacts with S100A13; this interaction is the first step in
CC the export of IL1A, followed by direct translocation of this complex
CC across the plasma membrane. {ECO:0000256|ARBA:ARBA00034134}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003753}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR RefSeq; XP_004399930.1; XM_004399873.2.
DR AlphaFoldDB; A0A2U3VWR1; -.
DR STRING; 9708.A0A2U3VWR1; -.
DR GeneID; 101382716; -.
DR KEGG; oro:101382716; -.
DR CTD; 3552; -.
DR InParanoid; A0A2U3VWR1; -.
DR OrthoDB; 4640109at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001660; P:fever generation; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR003295; IL-1_alpha.
DR InterPro; IPR020877; IL-1_CS.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003502; IL-1_propep.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078:SF33; INTERLEUKIN-1 ALPHA; 1.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR Pfam; PF00340; IL1; 1.
DR Pfam; PF02394; IL1_propep; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01358; INTRLEUKIN1A.
DR PRINTS; PR01357; INTRLEUKN1AB.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00253; INTERLEUKIN_1; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU003753};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|RuleBase:RU003753};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|RuleBase:RU003753};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyrogen {ECO:0000256|ARBA:ARBA00022620, ECO:0000256|RuleBase:RU003753};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU003753}.
FT DOMAIN 1..104
FT /note="Interleukin-1 propeptide"
FT /evidence="ECO:0000259|Pfam:PF02394"
SQ SEQUENCE 265 AA; 30445 MW; 24B38F8A3963982C CRC64;
MAKVPDLFED LKNCYSENEE YSSEIDHLSL NQKSFYDVSY DPLYEDCMSL STSKTSKTSQ
LTFKENVVVV AANGKVLKKR RLSLNQFITD DDLDGFTNDA EEEIMKPRSV AYNFHSNEKY
NYMRIIKSQF ILNDNLNQSI IQQTGGNNLM AAALQNLEDA AKFDMGAYTS EDSKLPVTLR
ISKTRLFVSA QNEDEPVLLK EMPETPKTIR DETNLLFFWE RHGTKNYFTS VAQPKLFIAT
QERKLVHMAR GQPSITDFQI LETQP
//
