ID A0A2U3VXV3_ODORO Unreviewed; 699 AA.
AC A0A2U3VXV3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Low-density lipoprotein receptor-related protein 8 isoform X4 {ECO:0000313|RefSeq:XP_004400396.1};
GN Name=LRP8 {ECO:0000313|RefSeq:XP_004400396.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004400396.1};
RN [1] {ECO:0000313|RefSeq:XP_004400396.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004400396.1; XM_004400339.2.
DR AlphaFoldDB; A0A2U3VXV3; -.
DR GeneID; 101368615; -.
DR CTD; 7804; -.
DR OrthoDB; 3918101at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 4.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|RefSeq:XP_004400396.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_004400396.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..699
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015613606"
FT TRANSMEM 620..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 246..285
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 332..378
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 379..421
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 422..465
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 466..510
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 46..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 53..71
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 65..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 85..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 92..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 147..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 250..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 699 AA; 77649 MW; 7BB2FABB3AEAACF4 CRC64;
MGRPERGALR PLAPLLLLLL LLRLQRLAAA AAADPQRGGQ GPVKECEEDQ FRCRNERCIP
SVWRCDEDDD CSDNSDEDDC PKKTCADSDF TCGNGHCIPE RWKCDGEEEC PDGSDESETT
CTKQVCPAEK LSCGPASHKC VPASWRCDGE KDCESGADEA GCATSLGTCR GDEFQCGDGT
CVPTIKRCNQ EQDCLDGSDE AGCLQGLNEC LHNNGGCSHI CTDLKIGFEC TCPAGYQLLD
QKTCGDIDEC EDPDACSQIC VNYKGYFKCE CHPGYEMDTL TKNCKAVAGR SPSLIFTNRH
EVRRIDLVKR DYSRLIPMLK NVVALDVEVA TNRIYWCDLS YRKIYSAYMD KASDPAEQEV
LMDEQLHSPE GLAVDWVHKH IYWTDSGNKT ISVATIDGGR RCTLFSRDLS EPRAIAVDPL
RGFMYWSDWG YQAKIEKSGL NGVDRQTLVS DNIEWPNGIT LDLLNQRLYW VDSKLHQLSS
IDLSGGNRKM LISSPDFLSH PFGIAVFEDK VFWTDLENEA IFSANRLNGL EISILAENLN
NPHDIVIFHE LKQPRAADAC ELSAQPNGGC EYLCLPAPQI SSPSPKYTCA CPDTMWLGPD
MKRCYRDGNE GGKMGSTVTA AVIGILVPMA VIALLCMSGY LIWRNWKRKN TKSMNFDNPV
YRKTTEEEDE DELHIGRTAQ TGHVYPARVA LSLEDDGLP
//
