ID   A0A2U3W0P0_ODORO        Unreviewed;       735 AA.
AC   A0A2U3W0P0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Vascular cell adhesion protein 1 isoform X1 {ECO:0000313|RefSeq:XP_004401525.1};
GN   Name=VCAM1 {ECO:0000313|RefSeq:XP_004401525.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004401525.1};
RN   [1] {ECO:0000313|RefSeq:XP_004401525.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR   RefSeq; XP_004401525.1; XM_004401468.2.
DR   AlphaFoldDB; A0A2U3W0P0; -.
DR   STRING; 9708.A0A2U3W0P0; -.
DR   GeneID; 101370513; -.
DR   KEGG; oro:101370513; -.
DR   CTD; 7412; -.
DR   InParanoid; A0A2U3W0P0; -.
DR   OrthoDB; 5359770at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   CDD; cd07689; IgC2_VCAM-1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   InterPro; IPR047012; ICAM_VCAM.
DR   InterPro; IPR003987; ICAM_VCAM_N.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008424; Ig_C2-set.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR003989; VCAM-1.
DR   PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR   PANTHER; PTHR13771:SF14; VASCULAR CELL ADHESION PROTEIN 1; 1.
DR   Pfam; PF05790; C2-set; 2.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13927; Ig_3; 2.
DR   PRINTS; PR01472; ICAMVCAM1.
DR   PRINTS; PR01474; VCAM1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SUPFAM; SSF48726; Immunoglobulin; 7.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..735
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015757434"
FT   TRANSMEM        696..716
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..101
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          219..305
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          308..393
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          507..591
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          596..680
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   735 AA;  80809 MW;  28BD44A3A955394E CRC64;
     MVVIFGASNV LWLVFAVSQA FKMEIFPENR VVAQIGDVIS LTCSTTGCEP PSFSWRTQID
     SPLNGKVRNE GSNSTLTMDP VSFNNEHAYV CTATCGSKKL EKGIQVEIYS FPKDPEIHLS
     GPLELEKPVT VTCLVPDVYP FDRLEINLLK GNDLLKNKEF LEPMEGKSLE TKSLEATFIP
     TKEDIGKALV CQAKLNIDEI DFEPKERETT KKLQVYISPK NTVISANPST RLQEGGSVTM
     TCSSEGLPAP QIFWSKKLDN GNLQLLSGNA TLTLIAMRIE DSGIYVCEGV NEVGKDGKEV
     ELIVQEKPFT VEISPGPQVI AQIGDSVVLT CGVTGCESPS FSWRTQIDSP LSGQVKTEGT
     KSTLTLSPVS FENGHSYLCT VTCGHKKLEK RISVDLYSFP RDPEIKMSGL LVSGNPVTVS
     CEVPSVYPSD RLEIELFKGE SIIESKTFLE DMDKKSLETK SLEMTFIPTT EDTGRVLICL
     AQLHVGEMEF EPKQRQSIQT LYVNVAPRDT TILVSPSSIL EEGSSVNMTC FSNGLPTPEI
     LWSRQLNNGH LQPLSENSTL TLTSTKMEDS GIYVCEGINQ AGISRKEVEL IIQVAPKDIQ
     LKAFPSESVK EGDTVIISCT CGNVPKTWII LKKKAETGDT VLKSRDGAYT IHKVQLEDAG
     VYECESKNEV GLQLRSLTLD VKGRENNKDY FSPELLVLYC ASSLIIPAIG IIIYLARRAN
     MKGSYSLVEA QKSKV
//