UniProt: A0A2U3W1F1

Database: UniProt
Entry: A0A2U3W1F1_ODORO

LinkDB:  A0A2U3W1F1_ODORO 
Original site:  A0A2U3W1F1_ODORO

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Ontology (6)   
   GO (6)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (22)   
   InterPro (13)   
   Pfam (6)   
   PROSITE (1)   
   SMART (2)   
All databases (31)   

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ID   A0A2U3W1F1_ODORO        Unreviewed;       854 AA.
AC   A0A2U3W1F1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT2 {ECO:0000313|RefSeq:XP_004401738.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004401738.1};
RN   [1] {ECO:0000313|RefSeq:XP_004401738.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR   RefSeq; XP_004401738.1; XM_004401681.2.
DR   AlphaFoldDB; A0A2U3W1F1; -.
DR   STRING; 9708.A0A2U3W1F1; -.
DR   GeneID; 101368050; -.
DR   KEGG; oro:101368050; -.
DR   CTD; 6773; -.
DR   InParanoid; A0A2U3W1F1; -.
DR   OrthoDB; 7823at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd10373; SH2_STAT2; 1.
DR   CDD; cd16846; STAT2_DBD; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR   Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR   Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR022756; STAT2_C.
DR   InterPro; IPR035854; STAT2_SH2.
DR   InterPro; IPR048988; STAT_linker.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR   PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12188; STAT2_C; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   Pfam; PF21354; STAT_linker; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF47655; STAT; 1.
DR   SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW   ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN          572..678
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
SQ   SEQUENCE   854 AA;  97887 MW;  8B4F3EE538BB920F CRC64;
     MAQWEMLQNL NNPFQDQLHQ LYSDSLLPMD IRQYLAVWIE DQNWQEAALG NDDSKATVLF
     FHFLDQLNNE CGRCSQDPER LLLQHNLRKF SRDIQAFPQG PTQLAEMIFN LLLEEKRILI
     QAQRVQLEQG EPTLEAPVES QQHEIESRIL ELKAMMEKLV KSICQLKDQQ DVFCFRYKIQ
     AQVNTLSLDP HQMRQRQLLQ ETLNELDKRR KEVLDATKAL LGQLTTLVEL LLPKLEEWKV
     QQQKACIGAP ADGGLEQLEK WFTAGAKLLF HLRQLLQELK GLSRLVSYQD DPLTKGVDLR
     KAQVTELLQH LLQRAFVVET QPCMPQTPHR PLILKTGSKF TVQTRLLVRL QEGNESLTAE
     VSIDRTPPQS QSFRKFNILT SNQKTLTPEK GQSQGLIWDF GYLTLVEQRS GGSGKGCNKG
     MLGVTEELHI ISITVKYTYQ GLKQELKTDT LPVVIISNMN QVSIAWASVL WFNLLSSNPQ
     NQQFFSSPPK APWSLLGPAL SWQFSSYVGR GLDPDQLSML RNKLFGQNSR TEGALLSWAD
     FTKRESPPGK LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERKLL KKTISGTFLL
     RFSETSEGGI TCSWVEHQDD DRVLIYSVQP FTKDVLQSLP LTKIIRHYQL LTEENIPENP
     LRFLYPRIPR DEAFGRYYQE KVNLQERRKY LKHKLIVVSN RQVDELQQLP DLKLEPEAGS
     LELELGLAPL LELEPGLELE PLLEMGLDLG PVLEPLVEPA PDVVQRASEP NVAPELKLEP
     VLDPESPAVP EQELPDDLRH LNTGEMEIFR NSMKIEEIMT NGDPLFAGQN TVDEAYVSHP
     SHFYMDGPLI PSDY
//

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