ID A0A2U3W205_ODORO Unreviewed; 1581 AA.
AC A0A2U3W205;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dynamin-binding protein {ECO:0000256|ARBA:ARBA00018186};
DE AltName: Full=Scaffold protein Tuba {ECO:0000256|ARBA:ARBA00032587};
GN Name=DNMBP {ECO:0000313|RefSeq:XP_004401963.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004401963.1};
RN [1] {ECO:0000313|RefSeq:XP_004401963.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus, Golgi stack
CC {ECO:0000256|ARBA:ARBA00004348}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_004401963.1; XM_004401906.1.
DR STRING; 9708.A0A2U3W205; -.
DR GeneID; 101363028; -.
DR KEGG; oro:101363028; -.
DR CTD; 23268; -.
DR InParanoid; A0A2U3W205; -.
DR OrthoDB; 25601at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11798; SH3_DNMBP_C1; 1.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR CDD; cd11794; SH3_DNMBP_N1; 1.
DR CDD; cd11795; SH3_DNMBP_N2; 1.
DR CDD; cd11796; SH3_DNMBP_N3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 6.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035820; DNMBP_SH3_C1.
DR InterPro; IPR035817; DNMBP_SH3_N1.
DR InterPro; IPR035818; DNMBP_SH3_N2.
DR InterPro; IPR035819; DNMBP_SH3_N3.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834:SF19; DYNAMIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00499; P67PHOX.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 6.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 6.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 6.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 66..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 145..204
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 243..302
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 789..972
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1013..1222
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 1290..1353
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1517..1580
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 216..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 715..760
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 350..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..658
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1581 AA; 177209 MW; 281A6ABD1CC13E5B CRC64;
MEAGSVVRAI FDFCPSVSEE LPLFVGDVIE VLAVVDEFWL LGRKEDVTGQ FPSSFVETVT
IPSLKAGERL FVCVCEFTSQ ELNSLPLHRG DLVILDGAPT APWLQGRSCW GARGFFPSSC
VRELCLSSQS RCWCPQSALL QIPEYSMGQA RALMGLSAQL DEELDFREGD VITIIGVPEP
GWFEGELEGR RGIFPEGFVE LLGPLRTVDE LVSSGNHDDC VINGEEETPT GEDERGPEDD
EEQLGTYGIA LYRFQALEPN ELDFEVGDKI RILGTLEDGW LEGSLKGRTG IFPYRFIKLF
SKTRAEEAMD PPQESSPTEI PAPSLGCSEN SLVVEGRRPE SPEYKAEKSN CVISETSASP
PEHLTSEYEV NKNSHQDEDT SGGAPRSPGL GHKQSLAKDS SAEDPSEIIN GVSSQPQVPF
PPRLQKHQYY STAGGGHQSS EQYADPLPFE ARTKDDSSLP PRGMSSPPKT LQKPVPPPHI
GSCLLGPRVV TPSQLSSPLQ GMARCAKKHH APKENASSFC SAPERSDMKL GLQDKVFTAE
AMALLHGEGN TDLDSKLTQQ LIEFEKSLSG PGLEQDKILR HFSIMDFNSE KDIVRGSSKL
TSQQELPERR KALRPPPPRP RTPASASPHV LLDQNLKPEP PLAMRPSRPA PLPPSAQHRG
TPVSPRLLTC TRPSCETPEK EGPESVDQTV DQTSQCPLVL VRVQEMEQDL DVGSRAQEEL
NLALEEKQDE SLREETLEDL EFYESNIESL NMELQQLREM TLLSSQSSSP VVPPGSVYTE
NPEQRMLEKR AKVIEELLQT ERDYVRDLEM CIEHIMVPLQ QAQIPNIDFE GLFGNMQMVI
KVSKQLLADL EISDAVGPVF LDHRDELEGT YKVYCQNHDE AISLLEIYEK DEKIQKHLQD
SLADLKSLYT EWGCTNYINL GSFLIKPVQR VMRYPLLLME LLNSTPESHP DKAPLTNAVL
AVKEINVNIN EYKRRKDLVL KYRKGDEDSL MEKISKLNIH SIIKKSNRVS SHLKHLTGFA
PQIKDEAFEE TEKNFRMQER LIKSFIRDLS LYLQHIRESA CVKVVAAVSM WDVCMEKGHR
DLEQFEKVHR YISDQLFTHF KERTERLVIS PLNQLLSMFT GPHKLVQKRF DKLLDFYNCT
ERAEKLKDKK TLEELQSARN NYEALNAQLL DELPKFQQFA QGLFTNCVHG YAEAHCDFVR
RALEQLKPLL SSLKVAGKEG NLTAVFHEEH SRVLQQLQVF TFFPESLPAA RKPFERKTTD
RPAARKPLLG LPSYMLQSEE LRASLLARYP PEKLFQAERN FNAAQDLDVS LLEGDLVGVI
KKKDPMGSQN RWLIDNGVST GFVYSSFLKP YNARRSQSDA SVGSHSSTES EPGGSSPRFP
RQNCSSTLTF NPSSMAVSFT SGSCQKQPQD ATSLKEPDQE TASASLNLGC SESSPSRCPT
DPDSSSQPRL WDFPEAGRDI HQPGPALRSS RNSRHLETVG HSLPGRNGQG KDLMKGCTRT
TQCLEDKNEE PESREAEGNQ VYFAVYTFKA RNPNELSVSA NQRLKILEFK DVTGNTEWWL
AEVNGKKGYV PSNYIRKTEY T
//
