ID A0A2U3W458_ODORO Unreviewed; 356 AA.
AC A0A2U3W458;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=C-X-C chemokine receptor type 2 {ECO:0000256|ARBA:ARBA00020033};
DE AltName: Full=High affinity interleukin-8 receptor B {ECO:0000256|ARBA:ARBA00033468};
GN Name=CXCR1 {ECO:0000313|RefSeq:XP_004402826.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004402826.1};
RN [1] {ECO:0000313|RefSeq:XP_004402826.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_004402826.1; XM_004402769.1.
DR AlphaFoldDB; A0A2U3W458; -.
DR STRING; 9708.A0A2U3W458; -.
DR GeneID; 101386791; -.
DR KEGG; oro:101386791; -.
DR CTD; 3577; -.
DR InParanoid; A0A2U3W458; -.
DR OrthoDB; 5347598at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR CDD; cd15178; 7tmA_CXCR1_2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000174; Chemokine_CXCR_1/2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF689; C-X-C CHEMOKINE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00427; INTRLEUKIN8R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_004402826.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..310
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 356 AA; 40184 MW; B15815CF9A139A53 CRC64;
MIVLLNDPWN ATDEWNYDEF GNFSGTPPTE TYSPCRIDDE TLNKYAVVVV YALVFVLSLL
GNSLVILVVL HSRVSQSVTD VYLLNLAIAD LLFALTLPLW AASKAKGWIF GTPLCKVVSL
LKEVNFYSGI LLLACISVDR YLAIVHATRT LIQKRHWVKF ICLGIWALSL ILSLPIFVFR
RAINPPYSSP VCYEDMGANT TKLRLVMRAL PQTFGFLLPL LVMLFCYGLT LRTLFQAHMG
QKHRAMRVIF AVVLVFLLCW LPYNLVLVAD TLMRLRVIKE TCERRNDIGR ALDATEILGF
LHSCLNPFIY AFIGQKFRHG LLKIMAFHGL ISKEYLSKDG RPSFVGSSSA NTSTTF
//
