ID A0A2U3W7C8_ODORO Unreviewed; 1753 AA.
AC A0A2U3W7C8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=A-kinase anchor protein 12 {ECO:0000313|RefSeq:XP_004404128.1};
GN Name=AKAP12 {ECO:0000313|RefSeq:XP_004404128.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004404128.1};
RN [1] {ECO:0000313|RefSeq:XP_004404128.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004404128.1; XM_004404071.1.
DR STRING; 9708.A0A2U3W7C8; -.
DR GeneID; 101374126; -.
DR KEGG; oro:101374126; -.
DR CTD; 9590; -.
DR InParanoid; A0A2U3W7C8; -.
DR OrthoDB; 4259343at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051018; F:protein kinase A binding; IEA:InterPro.
DR GO; GO:0010739; P:positive regulation of protein kinase A signaling; IEA:InterPro.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IEA:InterPro.
DR InterPro; IPR028540; AKAP12.
DR InterPro; IPR001573; AKAP_WSK.
DR PANTHER; PTHR23209; A-KINASE ANCHOR PROTEIN 12; 1.
DR PANTHER; PTHR23209:SF4; A-KINASE ANCHOR PROTEIN 12; 1.
DR Pfam; PF03832; WSK; 3.
DR PROSITE; PS51893; AKAP_CAM_BD; 3.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|PROSITE-ProRule:PRU01241};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT DOMAIN 589..609
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT DOMAIN 738..758
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT DOMAIN 783..803
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 589..609
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT MOTIF 738..758
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT MOTIF 783..803
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1566..1582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1753 AA; 188169 MW; BC230EB7CC568273 CRC64;
MGAGSSTEQR SPEQPEAGSA TPAEPEPEPS GGGLAAEAAP SALGDPAIAA ADPATKLLQK
NGQLSSANGL AEEEEFSPQE GALNGQEEEA IVTDVGQRES EDVSERASDK ATAAGSVVVQ
DMAKDGQEEM PEIIDQIPSS ESNLEELIQP TESQANDVGF KKVFKFVGFK FTVKKDKTEK
SDTVQLLTVK KDEGEGAGAA DGAGDHQEPS QETGEATAKE SELKQSTEKP QETLMREQSN
TEISVQAESG QAAEEHQEEG EEKQKEPTKS PDSPTSPVAS ETASPFKKFF TQGWAGWRKK
TSFRKPKEEK LEASEKKKDP EPEKVDTQEQ EKTDAASEKV DVPEQAHPQE ITESVNAARL
SAEYEKVELP SEDQVLGPPE EKPAPLATEV FDDRVEIVAD VHISMPETKT EEEKAEGEEA
GEPLPAEKGV ETQAELEKAA PAEELGKMKE VCAPGGDYTQ PTDLSPEEKA PSAHPEGVAS
EVDMLSSQER MKVQGSPLKK LFTSTGLKKL SGKKQKGKRE GGDEELGEHH QAAAESPDST
DEQKGESSAS SPEEPEEITC LEKGIADAHQ EGEAEEGTIS DGEKKREGVT PWASFKKMVT
PKKRVRRLSE SDKEDELDKV KSATLSSTES AASEMQEEAK GNGEEQKPEE PKRKVDTSVS
WEALICVGSS KKRARKASSS DDEGELKTMG GDSQKADDAG KDKDTGPDTA LASSQEHDQG
PGSSSPEQAG SPTEGEGVST WESFKRLVTP RKKSKSKLEE KSEDSVPGSG IEHSASDVEP
GKEESWVSIK KFIPGRRKKR SDGKAEQATV EDAGPAEVNE DDSDVPAVVP LSEYDAVERE
KTEAQQAQKS EEKPEQKVAV SVSEELSTSL VHGVTVTVLD GARAVSSVEE RSPSWISASV
TEPLEETEDE AKPLTGEVFE GEVLAEETSI VTKTLPEGQE AIGDTVVSEA ELTSEAVTAA
EGAEAFCAEE AAEASGAEET ADMVSAVSQL TDSPDTTEEA TPVQEVEGSV PDLEDQERRT
QEVLQAVAEK VREESPLPED TIQTVWEGGA KIPEKVEEAE EDSQGLDLKK ETDGVLEVRA
QEFKTETLTQ GEVVLQATPE SFEKVLPVTD SVESSELRTT CQAETLVGVK SELILEQAVA
PDSAETLTDS ETNGSTPVAD LEALHVTQQE QILEKHEDTE VASGTPSQVP EAEAVPAPKQ
VPPAPASFPS QEENKGHSEM EEVLEHPDKE IPVETVPILS KTDAIQEEGQ FTDRESQEKP
LLEGPDASAD PETTGSQEAT SEVALKEEAT RKPEFQKDDS IEVQSPTPSP APVEREMEAQ
GEREEMEAKP TQATEEELEQ KPAVTTSDEL SKQLVQTGSV AVIGGEKEVT AWEESSPQLV
QEEAVCTEVQ VQSSEASFTL TAAAVEEKVL GQTVKILEAA ETLESADAQS VPEEESSEKD
EEALTARPGD VEVPTGTEAQ PESIPVTVAA EPDGGISADL EGDETTPQSP SSREEDGPAA
CQEVQGSETR KEDLKAENEI SKLETESSKL VQNVIQTVVD QLVSTEETAA DFQTQAQPMI
SDTQEVRPHT ETEEEELQAQ DGTQAKEEST LTTVEQTHSD ISEAVSEASA EVTSVEVERS
SVYDQQLEEA VLLSEEKKQT TGTESVLEDG DRARLEGRIE ESLSESHEDE KGDAVDEPEN
QHSALEDAGS PGGLSKESPD TDGPTPKEKE GGQEVEFQEG KVHSESEEEI KTQTQDDTQK
QEGEPAKSEP TGS
//
