ID A0A2U3W9S4_ODORO Unreviewed; 593 AA.
AC A0A2U3W9S4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN Name=EIF2A {ECO:0000313|RefSeq:XP_004405070.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004405070.1};
RN [1] {ECO:0000313|RefSeq:XP_004405070.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993,
CC ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR RefSeq; XP_004405070.1; XM_004405013.2.
DR AlphaFoldDB; A0A2U3W9S4; -.
DR STRING; 9708.A0A2U3W9S4; -.
DR GeneID; 101378939; -.
DR KEGG; oro:101378939; -.
DR CTD; 83939; -.
DR InParanoid; A0A2U3W9S4; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 224..419
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 441..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65999 MW; 2734E48830BE7E81 CRC64;
MGFSFRDNMA PSTPLLTVRG SEGLYMVNGP PHFTESTLFS RESGKNCKVY TFSKDGTLFA
WGNGEKINVI NVTNKGLLHS FDLPKAVCLE FSPKNTVLAT WQPYTTSKDG TAGIPNLQLY
DVKTGTCFKS FIQKKMQNWC PSWSEDETIC ARNVNNEVHF FENNNFNTIA NKLHLQKIND
FVLSPGPQPY KVAVYVPGSK GAPSFVRLYQ YPNFDGPHAA LANKSFFKAD KVTMLWNKKA
TAVLVIASTD VDKTGASYYG EQTLHYIAAN GESAVVQLPK NGPIYDVVWN SSSTEFCAVY
GFMPAKATIF NLKCDPVFDF GTGPRNAAYY SPHGHILVLA GFGNLRGQME VWDVKNYKLI
SKPVASDSTY FAWCPDGEHI LTATCAPRLR VNNGYKIWHY TGSVLHKYDV PSNGELWQVS
WQPFLDGIFP VKTITYQAVP SDVPSEEPKV ATAYRPPALR NKPITNSKLH EEEPPQNMKP
QAGNDKPLSK TALKNQRKHE AKKAAKQEAR NEKSADLAPT PAPQSTPRNT ISQSTSGDPE
IDKKIKNLKK KLKAIEQLKE QAAAGKQLEK NQLEKIQKEK ALLQELEDLE LGV
//
