ID   A0A2U3WGJ3_ODORO        Unreviewed;      1057 AA.
AC   A0A2U3WGJ3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   Name=MAN2C1 {ECO:0000313|RefSeq:XP_004407839.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004407839.1};
RN   [1] {ECO:0000313|RefSeq:XP_004407839.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   RefSeq; XP_004407839.1; XM_004407782.2.
DR   AlphaFoldDB; A0A2U3WGJ3; -.
DR   STRING; 9708.A0A2U3WGJ3; -.
DR   GeneID; 101377330; -.
DR   KEGG; oro:101377330; -.
DR   CTD; 4123; -.
DR   InParanoid; A0A2U3WGJ3; -.
DR   OrthoDB; 2786490at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10813; GH38N_AMII_Man2C1; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT   DOMAIN          517..596
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1057 AA;  116916 MW;  6087AED8468F08E1 CRC64;
     MAAAPALKHW RTTLERVEKF VSPLYFTDCN LRGRLFRDSC PVAALSSFQT PERLPYQEAV
     QQEFRPAQIG DSFGPTWWTC WFRVELTIPE AWVGQEVHLR WESDGEGLVW RDGEPVQGLT
     TEGEKTSYVL TDRLEEGDPR SLTIYVEVAC NGLLGAGKGT MIAAPDPEKM FQVSRAELAV
     FCRDVHRLLV DLELLLGIAK GLGEDNQRSF QALYTANQMV NVCDPAQPET FPVAQALASR
     FFGQRGGESE HTIHAMGHCH IDTAWLWPFK ETVRKCARSW ASAVQLMEQN PDFIFACSQA
     QQLEWVKSHY PGLHARLQEF ACRGQFVPVG GTWVEMDGNL PSGEAMVRQF LQGQSFFLQE
     FGKMCSEFWL PDTFGYSAQL PQIMRSCGIR HFLTQKLSWN LVNSFPHHTF FWEGLDGSRV
     LAHFPPGDSY GMQGSVEEVL KTVVKNRDKG RSNHSAFLFG FGDGGGGPTQ TMVDRLKRLH
     NTDGLPRVQL SSPGRLFSAL ESSSGQLCTW VGELFLELHN GTYTTHAQIK KGNRECERIL
     HDVELLSSLA VARSAPFLYP AAQLQHLWRL LLLNQFHDVV TGSCIQLVAE EAMCHYENIR
     SHGNTLLSAA AAALCAGEPG PEGLLIVNTL PWKRTEVLAL PRPGGAHSLA FIPSPGDSAQ
     HGLCSCPCPH LTAAPADPAT CVCGAGVPAD SALRTPPAKT DGSVTLDNGI IRVRLDPTGC
     LTSLVLVASG REAIAEGTVG NQFVLFDDVP LYWDAWDVMD YHLETRKPVL GQAGTLAVGT
     EGGLRGSAWF LLQISPNSRL SQEVVLDIGC PYVRFHTEVH WHEAHKFLKV EFPARVRSPQ
     ATYEVQFGHL QRPTHHNTSW DWARFEVWAH RWIDLSEHGF GLALLNDCKY GASVRGNVLS
     LSLLRAPKAP DTTADMGRHE FTYALMPHKG SFQDAGVIRA AYSLNFPLLA LPASGPAPAA
     SWSAFSVSSP AVVLETVKQA ETSPQGRTLV LRLYEAHGSH VDCWLHTSLP VQEAVLCNLL
     EQRDPAGHLP LQDSRLKLTF SPFQVRSLLL LLQPPPN
//