ID   A0A2U3WJJ9_ODORO        Unreviewed;       913 AA.
AC   A0A2U3WJJ9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Calcium-activated chloride channel regulator 1 {ECO:0000256|ARBA:ARBA00041120};
GN   Name=LOC101384734 {ECO:0000313|RefSeq:XP_004409021.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004409021.1};
RN   [1] {ECO:0000313|RefSeq:XP_004409021.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the CLCR family.
CC       {ECO:0000256|ARBA:ARBA00006398}.
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DR   RefSeq; XP_004409021.1; XM_004408964.2.
DR   AlphaFoldDB; A0A2U3WJJ9; -.
DR   STRING; 9708.A0A2U3WJJ9; -.
DR   GeneID; 101384734; -.
DR   KEGG; oro:101384734; -.
DR   InParanoid; A0A2U3WJJ9; -.
DR   OrthoDB; 5479609at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR004727; CLCA_chordata.
DR   InterPro; IPR013642; CLCA_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; NF041940; choice_anch_X; 1.
DR   NCBIfam; TIGR00868; hCaCC; 1.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF52; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1; 1.
DR   Pfam; PF08434; CLCA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00023049};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..913
FT                   /note="Calcium-activated chloride channel regulator 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015744921"
FT   DOMAIN          306..475
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   913 AA;  100129 MW;  58D5B873AD2EE371 CRC64;
     MGSFKSSVFF LVLYLLEGAL SNSLIQLNNN GYEGIVIAID PNVPEDETLI QHIKDMVTQA
     SPYLFQATEK RFYFKNVAIL IPEKWKTKPE YVRPKLETYK NADVLVAEPN PAGNDEPYTE
     QMGNCGEKGE RIHFTPDFLA GKKSDIYGPQ ERVFVHEWAH LRWGVYDEYN NDKKFYLFNG
     RREAVRCSTG ITGKYRVQHC QGGSCIPKPC KIDTATGLYK EGCEFLPSRD QTEKASIMFS
     PSIGSVVEFC TEKNHNKEAP NAQNEKCNLR STWEVIKDSE DFKKTTPMTT QPPAPTFSLL
     QIGQRIVCLV LDKSGSMSNG DRLKRLNQAG KLFLLQIVEQ GSWVGMVTFD SAAQVQSELV
     QINSAAERDA LTKSLPTVAS GGTSICSGLR SAFAVIRKKF STDGSEIVLL TDGEDNTISS
     CFNEVKQSGA VIHTVALGPS AAKELEELSQ MTGGMRTYAS DQAQNNGLID AFGALSSGNG
     AASQRAIQLE SRGLTLQNNQ WMNGTVLVDS TVGNDTLFLI TWTTKHPQIL LHDPSGKKQD
     GFVVDTNTKM AYLQIPGTAK VGTWSYSLQA SSQTLTLTVT SRASSATLPP ITVTSKMNKD
     TGKFPSPMAV YAKIHQGSSP ILRATVTAVI ESVNGKTVTL ELLDNGAGAD ATKDDGIYSR
     YFTAYDTNGR YSMKVWALGG INAARQRVTP QQNGAMYMPG WIENGEIKWN PPRPEISKND
     LQGNQVCFSR TSSGGSFVAS GVPQAPIPDL FPPCQITDLK AKIHGDKFIN LTWTAPGDDY
     DHGRAHKYII RVSASILDLR DKFNESLQVN TSDLFPKEAN SKEVFVFTPE NIPFENGTDL
     FIAVQAVDKS NLKSEISNIV GVALFIPPQT PPEIPTPSPP CPDINVNSTI PGLHILKIMW
     KWLGELQLSV ALG
//