ID A0A2U3WJR0_ODORO Unreviewed; 184 AA.
AC A0A2U3WJR0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254};
GN Name=GREM1 {ECO:0000313|RefSeq:XP_004409079.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004409079.1};
RN [1] {ECO:0000313|RefSeq:XP_004409079.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR037254}.
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DR RefSeq; XP_004409079.1; XM_004409022.1.
DR AlphaFoldDB; A0A2U3WJR0; -.
DR SMR; A0A2U3WJR0; -.
DR STRING; 9708.A0A2U3WJR0; -.
DR KEGG; oro:101381879; -.
DR InParanoid; A0A2U3WJR0; -.
DR OrthoDB; 5347549at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR017159; Gremlin-1/2.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF3; GREMLIN-1; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR SMART; SM00041; CT; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR037254-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Secreted {ECO:0000256|PIRNR:PIRNR037254};
KW Signal {ECO:0000256|PIRNR:PIRNR037254}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT CHAIN 25..184
FT /note="Gremlin"
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT /id="PRO_5039776349"
FT DOMAIN 96..183
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
FT REGION 23..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 94..144
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 108..158
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 118..176
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 122..178
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
SQ SEQUENCE 184 AA; 20727 MW; 0A49859479D413A5 CRC64;
MSRTAYTVGA LLLLLGTLLP TAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS
IDLD
//
