ID   A0A2U3WKM3_ODORO        Unreviewed;       903 AA.
AC   A0A2U3WKM3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN   Name=DPP8 {ECO:0000313|RefSeq:XP_004409447.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004409447.1};
RN   [1] {ECO:0000313|RefSeq:XP_004409447.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   RefSeq; XP_004409447.1; XM_004409390.2.
DR   AlphaFoldDB; A0A2U3WKM3; -.
DR   STRING; 9708.A0A2U3WKM3; -.
DR   GeneID; 101365834; -.
DR   KEGG; oro:101365834; -.
DR   CTD; 54878; -.
DR   InParanoid; A0A2U3WKM3; -.
DR   OrthoDB; 170111at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..903
FT                   /note="dipeptidyl-peptidase IV"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015719418"
FT   DOMAIN          18..166
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          180..599
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          692..895
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   903 AA;  103682 MW;  D3C300AAD3991F80 CRC64;
     MKEGRPVNNF MCLIFLGKCN MAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY
     SWSQLKKLLA DTRKYHGYMM AKAPHDFMFV KRNDLDGPHS DRIYYLAMSG ENRENTLFYS
     EIPKTINRAA VLMLSWKPLL DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG
     TFLFQAGSGI YHVKDGGPQG FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSSDI
     WISNIVTREE RRLTYVHNEL ANMEEDPRSA GVATFVLQEE FDRYSGYWWC PEAETTGSVG
     SKILRILYEE NDESEVEIIH VTSPMLETRR ADSFRYPKTG TANPKVTFKM SEIMIDAEGR
     IIDVIDKELI QPFEILFEGV EYIARAGWTP EGKYAWSILL DRSQTRLQIV LISPELFIPV
     EDDAMERQRL IESVPDSVTP LIIYEETTDI WINIHDIFHV FPQSHEDEIE FIFASECKTG
     FRHLYKITSI LKESKYKRSS GGLPAPSDFK CPVKEEIAIT SGEWEVLGRH GSNIQVDEVR
     KLVYFEGTKD SPLEHHLYVV SYVNPGEVTR LTDRGYSHSC CISQHCDFFI SKYSNQKNPH
     CVSLYKLSSP EDDPACKTKE FWATILDSAG PLPDYTPPEI FSFESTTGFT LYGMLYKPHD
     LQPGKKYPTV LFIYGGPQVQ LVNNRFKGVK YFRLNTLASL GYVVVVIDNR GSCHRGLKFE
     GAFKYKMGQI EIDDQVEGLQ YLASQYDFID LDRVGIHGWS YGGYLSLMAL MQRSDIFRVA
     IAGAPVTLWI FYDTGYTERY MGHPDQNEQG YYLGSVAMQA EKFPSEPNRL LLLHGFLDEN
     VHFAHTSILL SFLVRAGKPY DLQIYPQERH SIRVPESGEH YELHLLHYLQ ENLGSRIAAL
     KVI
//