ID A0A2U3WRT6_ODORO Unreviewed; 2710 AA.
AC A0A2U3WRT6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=CHD6 {ECO:0000313|RefSeq:XP_004412021.1,
GN ECO:0000313|RefSeq:XP_004412022.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004412022.1};
RN [1] {ECO:0000313|RefSeq:XP_004412021.1, ECO:0000313|RefSeq:XP_004412022.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR RefSeq; XP_004412021.1; XM_004411964.1.
DR RefSeq; XP_004412022.1; XM_004411965.1.
DR STRING; 9708.A0A2U3WRT6; -.
DR GeneID; 101379672; -.
DR KEGG; oro:101379672; -.
DR CTD; 84181; -.
DR OrthoDB; 22878at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18668; CD1_tandem_CHD5-9_like; 1.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18058; DEXHc_CHD6; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850:SF2; -; 1.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 375..418
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 473..647
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 787..956
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1998..2060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2111..2139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2311..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2374..2394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2544..2597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2643..2710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2014..2045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2112..2139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2544..2559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2560..2578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2643..2659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2710 AA; 304496 MW; 04C2962D4D1BB689 CRC64;
MIMKIQKKEK QLSNLKVLNH SPMSDASVNF DYKSPSPFDR STDQEEKIED VASHCLPQKA
LYAAEEEAET LFPRKMTSHN GMEDSGGGGT GVKKKRKKKD VGESEGTAKG SRDREPKPKR
KREPREPKEA RKAKEPKRAK EPKEPKQKDG AKKARKPREA SGTKEAKEKR SSADSGARTK
SKKASKEQGP TPVERKKKGK RKSETTVESL ELDQGLPNSS LRSPEESTES ADSQKRRSGR
QVKRRKYNED LDFKVVDDDG ETIAVLGAGR TSALSASTLA WQAEEPPEDD ANIIEKILAS
KTVQEVHPGE PPFDLELFYV KYRNFSYLHC KWATMEELEK DPRIAQKIKR FRNKQAQMKH
IFTEPDEDLF NPDYVEVDRV LEVAHTKDAE TGEEVTHYLV KWCSLPYEES TWELEEDVDP
AKVKEFESLQ ILPEIKHVER PASDSWQKLE KSREYKNSNQ LREYQLEGMN WLLFNWYNRK
NCILADEMGL GKTIQSITFL SEIFLRGIHG PFLIIAPLST ITNWEREFRT WTEMNAIVYH
GSQISRQMIQ QYEMVYRDAQ GNPLSGVFKF HVVITTFEMI LADCPELKKI HWSCVIIDEA
HRLKNRNCKL LEGLKLMALE HKVLLTGTPL QNSVEELFSL LNFLEPSQFP SETAFLEEFG
DLKTEEQVKK LQSILKPMML RRLKDDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS
FLTKGANQHN MPNLINTMME LRKCCNHPYL INGAEEKILE DFRKTHSPDA PDFQLQAMIQ
AAGKLVLIDK LLPKLIAGGH KVLIFSQMVR CLDILEDYLI QRRYTYERID GRVRGNLRQA
AIDRFCKPDS DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK
AVKVYRLITR NSYEREMFDK ASLKLGLDKA VLQDINRKGS TNGVQQLSKM EVEDLLRKGA
YGALMDEEDE GSKFCEEDID QILQRRTHTI TIQSEGKGST FAKASFVASG NRTDISLDDP
NFWQKWAKIA ELDTEAKNEK ESLVIDRPRV RKQTKHYNSF EEDELMEFSE LDSDSDERPT
RSRRLNDKTR RYLRAECFRV EKNLLIFGWG RWKDILTHGR FKWHLNEKDM EMICRALLVY
CVKHYKGDEK IKSFIWELIT PTKDGQAQTL QNHSGLSAPV PRGRKGKKTK NQLLLPELKN
ADWLATCNPE VVLHDDGYKK HLKQHCNKVL LRVRMLYYLK AEILGEAAEK AFEGTPAREL
EVPLPDIDYV EIPVDWWDAE ADKSLLIGVF KHGYERYNAM RADPALCFLE KVGMPDEKSL
SAEQGVTDGT SDIPDRGNMD KEDNTEDKLD GLQKQMESSR DGGDGIFGEQ KDDNQAAQDG
SDPDRSPWPV SSALTARLRR LVTIYQRCNR KELCRPEILG PGNQGYWVQE EMFRRTSEMD
LINKEAQKRW TRREQADFYR AVSSFGVVYD QEKKTFDWTQ FRIISRLDKK SDESLEHYFY
SFVAMCRNVC RLPTWKDGGP PDPSIYVEPI TEERAARTLY RIELLRKVRE QVLRCPQLHE
RLQLCRPSLY LPVWWECGKH DRDLLVGTAK HGLNRTDYYV MTDPQLSFLD AYRNYARHKR
TDTQAPESLC CLYQTSSKLY ESLTYTQMSR TSEPLESEPE NLVKIEGRDD HPAAPAGSLS
DMPCENFISK VQDVISIPHD ERLLPESLEG MMYGKRALSR EPGSFQESPT TRTEPRRDAL
AVSASEDGNW QPGGREAETP AGPSFMDSLE AGVAQMNIKN GKHLLLSLSR EGELCSDTGQ
RPESIGQLEA KCLASPSLDQ GNESGFVDIC NLSVCDSRRS LSSDRQLIDL LENKSLESKL
VLSQNHSDEE EEEEENEEEN VGAAAGLRQR PEVVRLAEPT ADILREKSRG FHVEEAMSQS
PGPQGPFPQA ACLCHCKHTE GWTRGLESEE SEVEKPKGYN PDMYKSKTNS ITVEAEPPAP
LAEPCQGKHE LLKEPWKDSA EGRKGFPAYP EASELKSEDM DFESKDDYDR DGNGHVQDYP
GKYSEEESKS STSGIAGDLG DDLQEARAPT IAQLLQEKTL FSFSEWPKDR VIINRLDNIC
HVVLKGKWPS GQQYEPSGTL PPPVLSSSAG SRGSLSEPEA TELGFSSSAA LVAPIQKETF
LAPVFTKDDQ KHRCPYEFEV ERDAKARSLE QFSATHGHPP IVLNGWHGES AIDLSCTSEG
SPGATSPFPV SASTPKVGAI GSLQGALGMD LSGILQAGLI HPVTGQIVNG SLRRDDAATR
RRRGRRKHVE GGMDLIFLKE QTLQAGILEV HEDPGQAPPN TSHPEGPVAA TSAPEPAPAA
GSQAEKAIPS KSLLDWLRQQ ADYSLEVPGF GANFSDKPKQ RRPRCKEPGK LDVNSLSGEE
RVPAVPKEPG LRGFLPENKF NHTLAEPVLR DAGPRRRGRR PRSELLKAPA IAADSPSRMG
PLFMNGLIAG MDLVGLQNMR NMPGIPLTGL VGLPAGFAAV PAGEESRSTL SMLPMVLPGM
AAVPQMFGLG GLLNAPMATT CTSTAPAPLS STTKSGPSAP EKTVEDKPSS HNVKSDTLAE
DKPGPGPFSD QSEPAITTSS PVAFNPFLIP GVSPGLIYPS MFLSPGMGMA LPAMQQARHS
EVIGLESQKR KKKKTKGDSL NPNPEPAPGS EKEPGSDQNC PESRTPGPLD REHAAQTREG
GLKDSNSDTN
//
