ID A0A2U3WSC2_ODORO Unreviewed; 577 AA.
AC A0A2U3WSC2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mucolipin-1 {ECO:0000313|RefSeq:XP_004412233.1};
GN Name=MCOLN1 {ECO:0000313|RefSeq:XP_004412233.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004412233.1};
RN [1] {ECO:0000313|RefSeq:XP_004412233.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004412233.1; XM_004412176.1.
DR AlphaFoldDB; A0A2U3WSC2; -.
DR STRING; 9708.A0A2U3WSC2; -.
DR GeneID; 101363074; -.
DR KEGG; oro:101363074; -.
DR CTD; 57192; -.
DR InParanoid; A0A2U3WSC2; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21070; ELD_TRPML1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047316; ML1_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..282
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 382..521
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 64729 MW; 07C7DA59D6FEA075 CRC64;
MAAPVGRRGS ETERLLTPSP GYGTQAGASP VPPEEEDLRR RLKYFFMSPC DKFRAKGRKP
FKLMLQVVKI LVVTVQLILF GLSNQLAVTF REENTIAFRH LFLLGYSDGA DDTFAAYTRE
QLYQAIFHAV DQYLMLPDVS LGRYAYVRGG GGPWANGSAL ALCQQYYHRG HVDPANDTFD
IDPMVVTDCI QVDPPERPLV PPSDDLSLSD GSASYKNLTL KFHKLINVTI HFQLKTINLQ
SLINNEIPDC YTFSVLITFD NKAHSGRIPI SLETQAHIQE CKHPSVFRHG DNSFRLLFDV
VVILTCSFSF LLCARSLLRG FLLQNEFVGF MWRQRGRVIS LWDRLEFVNG WYILLVTSDV
LTISGTIMKI GIEAKNLASY DVCSILLGTS TLLVWVGVIR YLTFFHKYNI LIATLRVALP
SVMRFCCCVA VIYLGYCFCG WIVLGPYHVK FRSLSMVSEC LFSLINGDDM FVTFAAMQAQ
QGRSSLVWLF SQLYLYSFIS LFIYMVLSLF IALITGAYDT IKHPGGAGAE ESELQAYIAQ
CRDSPTSGKF RRGSGSACSL LCCCGRDASE EHSLLVN
//
