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Database: UniProt
Entry: A0A2U3WSQ5_ODORO
LinkDB: A0A2U3WSQ5_ODORO
Original site: A0A2U3WSQ5_ODORO 
ID   A0A2U3WSQ5_ODORO        Unreviewed;       183 AA.
AC   A0A2U3WSQ5;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Histone H2B type 1-A-like {ECO:0000313|RefSeq:XP_004412274.1};
GN   Name=LOC101378601 {ECO:0000313|RefSeq:XP_004412274.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004412274.1};
RN   [1] {ECO:0000313|RefSeq:XP_004412274.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC       {ECO:0000256|ARBA:ARBA00002001}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA. {ECO:0000256|ARBA:ARBA00011538}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the histone H2B family.
CC       {ECO:0000256|ARBA:ARBA00006846}.
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DR   RefSeq; XP_004412274.1; XM_004412217.1.
DR   AlphaFoldDB; A0A2U3WSQ5; -.
DR   STRING; 9708.A0A2U3WSQ5; -.
DR   KEGG; oro:101378601; -.
DR   InParanoid; A0A2U3WSQ5; -.
DR   OrthoDB; 5204105at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000558; Histone_H2B.
DR   PANTHER; PTHR23428:SF367; H2B.W HISTONE 2; 1.
DR   PANTHER; PTHR23428; HISTONE H2B; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00621; HISTONEH2B.
DR   SMART; SM00427; H2B; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT   DOMAIN          94..158
FT                   /note="Histone H2A/H2B/H3"
FT                   /evidence="ECO:0000259|Pfam:PF00125"
SQ   SEQUENCE   183 AA;  20597 MW;  8638ECF3876B5DEE CRC64;
     MWRLPVTSGN AATINGPVPL SHRHCPSFRA VGKVRPTWLS LAVRPLLRKA WAQTEDPTAA
     DPNSPKQKQP TRQCCRCCCH HHPLNNTAPP SPLQFHHLFP RVLRHVHKGL SPSQTTVSIM
     DSFVKDIFKH IAEEASCLAR STNRSTITSR EIQTAVHLLL PREIGKHDVS EATKAIIRYT
     FRQ
//
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