ID A0A2U3WT51_ODORO Unreviewed; 2591 AA.
AC A0A2U3WT51;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Filamin-B isoform X3 {ECO:0000313|RefSeq:XP_004412435.1};
GN Name=FLNB {ECO:0000313|RefSeq:XP_004412435.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004412435.1};
RN [1] {ECO:0000313|RefSeq:XP_004412435.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR RefSeq; XP_004412435.1; XM_004412378.1.
DR GeneID; 101382948; -.
DR CTD; 2317; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21309; CH_FLNB_rpt1; 1.
DR CDD; cd21313; CH_FLNB_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 249..347
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 349..446
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 447..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 544..636
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 640..736
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 737..839
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 840..938
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 939..1034
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1035..1127
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1128..1222
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1223..1322
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1323..1415
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1416..1511
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1512..1608
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1609..1704
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1747..1805
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1805..1897
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1908..1983
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1986..2078
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2076..2174
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2177..2269
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2271..2364
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2368..2460
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2496..2590
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 244..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2591 AA; 276519 MW; 147726245F5C1DAD CRC64;
MPVTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKRIGNL QTDLSDGLRL IALLEVLSQK
RMYRKYHQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLVWTLILH
YSISMPVWED EGDDDAKKQT PKQRLLGWIQ NKIPYLPITN FNQNWQDGKA LGALVDSCAP
GLCPDWESWD PRKPVDNARE AMQQADDWLG VPQVITPEEI IHPDVDEHSV MTYLSQFPKA
KLKPGAPLKP KLNPKKARAY GRGIEPTGNM VKQPAKFTVD TISAGQGEVM VFVEDPEGNK
EEAQVTPDSD KNKTYSVEYL PKVTGLHKVT VLFAGQHISK SPFEVNVDKA QGDASKVTAK
GPGLEAAGNI ANKPTYFDIY TAGAGVGDIG VEVEDPQGKN TVELLVEDKG NQVYRCVYKP
LQPGPHVVKV SFAGDTIPKS PFIVQVGEAC SPNACRASGR GLQPKGIRIR ETADFKVDTK
AAGSGDLGVT VKGPKGLEEL VKQKGFLDGV YAFEYYPSTP GKYSIAIAWG GHHIPKSPFE
VQVGPEAGMQ KVRAWGPGLH SGIVGRSADF VVESIGSEVG SLGFAIEGPS QAKIEYDDQN
DGSCDVKYWP KEPGEYAVHI MCDDEDIKDS PYMAFIHPAA GDYNPDLVQA YGPGLEKSGC
IVNNLCEFTV DPKDAGKAPL KIFAQDGEGQ PIDIQMKSRM DGTYACSYTP VKAIKHTIAV
VWGGVNIPHS PYRVSIGQGS HPQKVKVFGP GVERSGLKAN EPTHFTVDCT EAGEGDVSVG
IKCDARVLSE DEEDVDFDII HNANDTFTVK YVPPAAGRYT IKVLFASQEI PASPFRVKVD
PSHDASKVKA EGPGLSKAGV ENGKPTHFTV YTKGAGKAPL NVQFSSALPG DAVKDLDIID
NYDYSHTVKY TPTQQGCMQV LVTYGGDPIP KSPFTVGVAA PLDLSKIRIN GLENRVEVGK
GQEFAIDTKG AGGQGKLDVT ILSPSRKVVP CMVAPVVGRE SSTAKFIPRE EGLYAVDVTY
DGHPVPGSPY TVEASLPPDP TKVKAHGPGL EGGLVGKPAE FTIDTKGAGT GGLGLTVEGP
CEAKIECSDN GDGTCSVSYL PTKPGEYFVN ILFEEVHIPG SPFKADIEMP FDPSKVVALG
PGLQHGKVGE AGLLSVDCSE AGPGALGLEA ISDSGAKAEV CIENNKDGTY AVTYVPLTAG
MYTLTMKYGG ELVPHFPARV KVEPAVDTSR VKVFGPGIEG KDVFREATTD FTVDSRPLTQ
VGGDHIKAHI ANPSGASTEC FVTDNADGTY QVEYTPFEKG LHVVEVTYDD VPIPHSPFKV
AVTEGCQPSR VQAQGPGLKE AFTNKPNVFT VVTRGAGIGG LGITVEGPSE SKINCRDNKD
GSCSAEYIPF APGDYDVNIT YGGAHIPGSP FRVPVKDVVD PSKVKVAGPG LGSSVRARIL
QSFTVDSSKA GLAPLEVRVL GPRGLVEPVN IVDNGDGTHT VTYTPSQEGP YMVSVKYADE
EIPRSPFKVK VLPTYDASKV TASGPGLSSY GVPASLPVEF AIDARDAGEG LLAVQITDQE
GKPKRAIVHD NEDGTYAVTY IPDKTGRYMI GVTYGGDDIP LSPYRIRATQ TGDASKCLAT
GPGIASTVKT GEEVGFVVDA KTAGKGKVTC TVLTPDGTEA EADVIENEDG TYDIFYTAAK
PGTYVIYVRF GGVDIPNSPF TVMATDGEVE AVEEAPVTEE AYVPVSDMNG LGFKPFDLVI
PFAVRKGEIT GEVHMPSGKT ATPEIVDNKD GTVTVRYAPT EVGLHEMHIK YMGSHIPESP
LQFYVNYPNS GSVSAYGPGL VYGVANKTAT FTIVTEDAGE GGLDLAIEGP SKAEISCIDN
KDGTCTVTYL PTLPGDYSIL VKYNDKHIPG SPFTAKITDD SRRCSQVKLG SAADFLLDIS
ETDLSTLTAS IKAPSGRDEP CLLKRLPNNH IGISFIPREV GEHLVSIKKN GNHVANSPVS
IMVVQSEIGD ARRAKVYGRG LSEGRTFEMS EFIVDTRDAG YGGISLAVEG PSKVDIQTED
LEDGTCKVSY FPTVPGVYIV STKFADEHVP GSPFTVKISG EGRVKESITR TSRAPSVATV
GSICDLNLKI PEIDSSDMSA HVTSPSGRIT EAEIVSVGKN SHCVRFVPQE MGVHTVSVKY
RGQHVTGSPF QFTVGPLGEG GAHKVRAGGP GLERGEAGVP AEFSIWTREA GAGGLSIAVE
GPSKAEITFD DHKNGSCGVS YIAQEPGNYE VSIKFNDEHI PESPYLVPVI APSDDARRLT
VMSLQESGLK VNQPASFAIR LNGAKGKIDA KVHSPSGAVE ECHVSELEPD KYAVRFIPHE
NGIHTIDVKF NGSHVVGSPF KVRVGEPGQA GNPALVSAYG AGLEGGTTGI QSEFFINTTR
AGPGTLSVTI EGPSKVKMDC QETPEGYKVM YTPMAPGSYL IGVKYGGPNH IVGSPFKAKV
TGQRLVSPGS TNETSSILVE SVTRSSTETC YSAVPKASSD ASKVTSKGAG LSKAFVGQKS
SFLVDCSKAG SNMLLIGVHG PTTPCEEVSM KHVGNQQYNV TYVVKEKGDY VLAVKWGEEH
IPGSPFHVTV P
//
