ID   A0A2U3WUA3_ODORO        Unreviewed;       495 AA.
AC   A0A2U3WUA3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|RefSeq:XP_004412884.1};
GN   Name=ENTPD2 {ECO:0000313|RefSeq:XP_004412884.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004412884.1};
RN   [1] {ECO:0000313|RefSeq:XP_004412884.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_004412884.1; XM_004412827.1.
DR   AlphaFoldDB; A0A2U3WUA3; -.
DR   STRING; 9708.A0A2U3WUA3; -.
DR   GeneID; 101374840; -.
DR   KEGG; oro:101374840; -.
DR   CTD; 954; -.
DR   InParanoid; A0A2U3WUA3; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        461..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         204..208
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   495 AA;  53910 MW;  91C88D60C1A0B72B CRC64;
     MAGKVLSLLP PLLLAVAGLT GLLLLYVPTR DVRELPALKY GIVLDAGSSH TSMFIYKWPA
     DKENDTGIVG QHSSCDVRGG GISSYADNPS RAGQSLVECL DQALQDVPKE RHVGTPLYLG
     ATAGMRLLNL TSPEASANVL AAVTQTLTQY PFDFRGAHIL SGQDEGVFGW VTANYLLENF
     IKYGWVGRWF QPRKGTLGAM DLGGASTQIT FETASPAEDP ANEVQLRLYG QHYRVYTHSF
     LCYGRDEVLR RLLAGALQTH GFHPCWPRGY STQVLLQDVY ESPCTAAQRP QAFNNSTRVS
     LSGTSNPALC RSLIMGLFNF SSCRFSRCSF NGIFQPPVAG NFIAFSAFFY TMNFLRTVMG
     LPVATLQQLE AAVVTVCNQT WNELQSRAPG ERARLPDYCA GAMFVQQLLS RGYGFHERAF
     GGVTFQKKAG DTAVGWALGY MLNLTNLIPA EPPALRKGTD FGAWVVLVLL CAAMLLAAFV
     LLLRQARSAK SSGAI
//