ID A0A2U3WWP6_ODORO Unreviewed; 543 AA.
AC A0A2U3WWP6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Organic anion transporter 3 {ECO:0000256|ARBA:ARBA00040389};
DE AltName: Full=Organic anion/dicarboxylate exchanger {ECO:0000256|ARBA:ARBA00041389};
DE AltName: Full=Solute carrier family 22 member 8 {ECO:0000256|ARBA:ARBA00042097};
GN Name=SLC22A8 {ECO:0000313|RefSeq:XP_004413851.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004413851.1};
RN [1] {ECO:0000313|RefSeq:XP_004413851.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a
CC dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) +
CC a dicarboxylate(out); Xref=Rhea:RHEA:76071, ChEBI:CHEBI:28965,
CC ChEBI:CHEBI:59560; Evidence={ECO:0000256|ARBA:ARBA00036443};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) +
CC 2-oxoglutarate(out); Xref=Rhea:RHEA:72511, ChEBI:CHEBI:16347,
CC ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036065};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) +
CC glutarate(out); Xref=Rhea:RHEA:72515, ChEBI:CHEBI:16347,
CC ChEBI:CHEBI:30921; Evidence={ECO:0000256|ARBA:ARBA00035971};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-
CC yl)acetate(in) + a dicarboxylate(out); Xref=Rhea:RHEA:75983,
CC ChEBI:CHEBI:28965, ChEBI:CHEBI:30854;
CC Evidence={ECO:0000256|ARBA:ARBA00036697};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) =
CC 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in);
CC Xref=Rhea:RHEA:72543, ChEBI:CHEBI:16810, ChEBI:CHEBI:57905;
CC Evidence={ECO:0000256|ARBA:ARBA00036744};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(in) + prostaglandin E2(out) = 2-
CC oxoglutarate(out) + prostaglandin E2(in); Xref=Rhea:RHEA:72499,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:606564;
CC Evidence={ECO:0000256|ARBA:ARBA00036652};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2-
CC oxoglutarate(out) + prostaglandin F2alpha(in); Xref=Rhea:RHEA:72507,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:57404;
CC Evidence={ECO:0000256|ARBA:ARBA00036566};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) +
CC taurocholate(in); Xref=Rhea:RHEA:72547, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00036242};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-
CC oxoglutarate(in) + estrone 3-sulfate(out); Xref=Rhea:RHEA:72399,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:60050;
CC Evidence={ECO:0000256|ARBA:ARBA00036034};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) +
CC glutarate(out); Xref=Rhea:RHEA:71751, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:30921; Evidence={ECO:0000256|ARBA:ARBA00036317};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) +
CC urate(out); Xref=Rhea:RHEA:72403, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:17775; Evidence={ECO:0000256|ARBA:ARBA00035801};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a
CC dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in)
CC + a dicarboxylate(out); Xref=Rhea:RHEA:75995, ChEBI:CHEBI:28965,
CC ChEBI:CHEBI:194524; Evidence={ECO:0000256|ARBA:ARBA00035829};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a
CC dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in);
CC Xref=Rhea:RHEA:76075, ChEBI:CHEBI:28965, ChEBI:CHEBI:43029;
CC Evidence={ECO:0000256|ARBA:ARBA00036842};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + L-sepiapterin(out) = a
CC dicarboxylate(out) + L-sepiapterin(in); Xref=Rhea:RHEA:76079,
CC ChEBI:CHEBI:28965, ChEBI:CHEBI:194527;
CC Evidence={ECO:0000256|ARBA:ARBA00036118};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + N-benzoylglycine(out) = a
CC dicarboxylate(out) + N-benzoylglycine(in); Xref=Rhea:RHEA:75991,
CC ChEBI:CHEBI:28965, ChEBI:CHEBI:606565;
CC Evidence={ECO:0000256|ARBA:ARBA00036837};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + indoxyl sulfate(out) = a
CC dicarboxylate(out) + indoxyl sulfate(in); Xref=Rhea:RHEA:75987,
CC ChEBI:CHEBI:28965, ChEBI:CHEBI:144643;
CC Evidence={ECO:0000256|ARBA:ARBA00036886};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) +
CC kynurenate(in); Xref=Rhea:RHEA:76087, ChEBI:CHEBI:28965,
CC ChEBI:CHEBI:58454; Evidence={ECO:0000256|ARBA:ARBA00035812};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dehydroepiandrosterone 3-sulfate(out) + glutarate(in) =
CC dehydroepiandrosterone 3-sulfate(in) + glutarate(out);
CC Xref=Rhea:RHEA:72355, ChEBI:CHEBI:30921, ChEBI:CHEBI:57905;
CC Evidence={ECO:0000256|ARBA:ARBA00036447};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in)
CC + glutarate(out); Xref=Rhea:RHEA:72151, ChEBI:CHEBI:30921,
CC ChEBI:CHEBI:60050; Evidence={ECO:0000256|ARBA:ARBA00036402};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutarate(in) + prostaglandin E2(out) = glutarate(out) +
CC prostaglandin E2(in); Xref=Rhea:RHEA:72495, ChEBI:CHEBI:30921,
CC ChEBI:CHEBI:606564; Evidence={ECO:0000256|ARBA:ARBA00036929};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) +
CC prostaglandin F2alpha(in); Xref=Rhea:RHEA:72503, ChEBI:CHEBI:30921,
CC ChEBI:CHEBI:57404; Evidence={ECO:0000256|ARBA:ARBA00035764};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutarate(in) + taurocholate(out) = glutarate(out) +
CC taurocholate(in); Xref=Rhea:RHEA:72159, ChEBI:CHEBI:30921,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00036154};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutarate(out) + urate(in) = glutarate(in) + urate(out);
CC Xref=Rhea:RHEA:72551, ChEBI:CHEBI:17775, ChEBI:CHEBI:30921;
CC Evidence={ECO:0000256|ARBA:ARBA00036110};
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family.
CC {ECO:0000256|ARBA:ARBA00009203}.
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DR RefSeq; XP_004413851.1; XM_004413794.2.
DR AlphaFoldDB; A0A2U3WWP6; -.
DR STRING; 9708.A0A2U3WWP6; -.
DR GeneID; 101381620; -.
DR KEGG; oro:101381620; -.
DR CTD; 9376; -.
DR InParanoid; A0A2U3WWP6; -.
DR OrthoDB; 2088942at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00898; 2A0119; 1.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF439; SOLUTE CARRIER FAMILY 22 MEMBER 8; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Detoxification {ECO:0000256|ARBA:ARBA00022575};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 125..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..498
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 515..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 59733 MW; F6C375E55F682EF3 CRC64;
MAFSELMDRV GSKGPFQFLN TILLSLPILG LANHYLLQIF TATTPDHHCR PPPNASTGPW
VLPKGLNGKA EKCLRFIHPP NATVPNDTQG ATEPCLDGWA YDLSTADSIV TEWDLVCESR
RLKEVAQSVF MAGTLIGGIV LGDLSDRFGR KPILTCSYLL LAASGSGAAF SPNVSIYMVF
RFLCGWSISG IVLSTVILNV ECLSIQMRAI MSTLTGYFYT CGQFVLPGLA YAIPQWRWLQ
LTVSIPFFAF FLLSWWIPES VRWMVLSGKF SKALKILRQI AALNGKKEEG KKLSVEELKL
IMQKEISLAK AKYSIADLFR TPNMRRVTCC LSLAWFSTGF GYYSLAMGVE EFGVNLYILQ
LIFGGVDIPA KFITVLSINY LGRHVTQASS LLLAGGSILA IIFVPSDLQT LRTVLAVFGK
GCLSSSFSCL FLYTTELYPT VIRQTGMGIS NLWTRAGSMS APLVKITGEL QPFIPSIIFG
TVTLLGGSAA YFLPETLNRP LPETIQDMET WSWRAKKTKQ EPEAEKASQR IPLQSCGPGL
DPS
//
