ID   A0A2U3WYF9_ODORO        Unreviewed;       687 AA.
AC   A0A2U3WYF9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Dihydropyrimidinase-related protein 3 isoform X1 {ECO:0000313|RefSeq:XP_004414687.1};
GN   Name=DPYSL3 {ECO:0000313|RefSeq:XP_004414687.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC   Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004414687.1};
RN   [1] {ECO:0000313|RefSeq:XP_004414687.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent
CC       remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal
CC       growth cone collapse and cell migration.
CC       {ECO:0000256|ARBA:ARBA00025548}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC       {ECO:0000256|ARBA:ARBA00004624}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Hydantoinase/dihydropyrimidinase family.
CC       {ECO:0000256|ARBA:ARBA00008829}.
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DR   RefSeq; XP_004414687.1; XM_004414630.2.
DR   AlphaFoldDB; A0A2U3WYF9; -.
DR   STRING; 9708.A0A2U3WYF9; -.
DR   GeneID; 101382773; -.
DR   KEGG; oro:101382773; -.
DR   CTD; 1809; -.
DR   InParanoid; A0A2U3WYF9; -.
DR   OrthoDB; 1772494at2759; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   CDD; cd01314; D-HYD; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011778; Hydantoinase/dihydroPyrase.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR02033; D-hydantoinase; 1.
DR   PANTHER; PTHR11647:SF57; DIHYDROPYRIMIDINASE-RELATED PROTEIN 3; 1.
DR   PANTHER; PTHR11647; HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 2.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT   DOMAIN          181..570
FT                   /note="Amidohydrolase-related"
FT                   /evidence="ECO:0000259|Pfam:PF01979"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  74016 MW;  FB70D7654736C44F CRC64;
     MASGRRGWDS SHEDDLPVYL ARPGTTDQVP RQKYGGMFCN VEGAFESKTL DFDALSVGQR
     GAKTPRSGQG SGRGSGSRPG VEGDSPRRGQ GREEGREPAP ASPASPAPAG VEIRSATGKE
     VLQNLGPKDK SDRLLIKGGR IVNDDQSFYA DIYMEDGLIK QIGDNLIVPG GVKTIEANGK
     MVIPGGIDVH THFQMPYKGM TTVDDFFQGT KAALAGGTTM IIDHVVPEPE ASLTEAYEKW
     REWADGKSCC DYALHVDITH WNDSVKQEVQ NLIKDKGVNS FMVYMAYKDL YQVSNTELYE
     IFTCLGELGA IAQVHAENGD IIAQEQTRML EMGITGPEGH VLSRPEELEA EAVFRAITIA
     SQTNCPLYVT KVMSKSAADL ISQARKKGNV VFGEPITASL GTDGTHYWSK NWAKAAAFVT
     SPPLSPDPTT PDYINSLLAS GDLQLSGSAH CTFSTAQKAI GKDNFTAIPE GTNGVEERMS
     VIWDKAVATG KMDENQFVAV TSTNAAKIFN LYPRKGRISV GSDSDLVIWD PDAVKIVSAK
     NHQSAAEYNI FEGLELRGAP LVVICQGKIM LEDGNLHVTQ GAGRFIPCSP FSDYVYKRIK
     ARRKMADLHA VPRGLYDGPV FDLTTTPKGG TPAGSTRGSP TRPNPPVRNL HQSGFSLSGT
     QVDEGVRSAS KRIVAPPGGR SNITSLS
//