ID A0A2U3X0K0_ODORO Unreviewed; 3476 AA.
AC A0A2U3X0K0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein isoform X1 {ECO:0000313|RefSeq:XP_004415557.1};
GN Name=ASPM {ECO:0000313|RefSeq:XP_004415557.1};
OS Odobenus rosmarus divergens (Pacific walrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae;
OC Odobenus.
OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_004415557.1};
RN [1] {ECO:0000313|RefSeq:XP_004415557.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004415557.1; XM_004415500.1.
DR STRING; 9708.A0A2U3X0K0; -.
DR GeneID; 101368404; -.
DR KEGG; oro:101368404; -.
DR CTD; 259266; -.
DR InParanoid; A0A2U3X0K0; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000245340; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 36.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 62.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 18.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 36.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245340}.
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3476 AA; 408319 MW; 621F7FE87F578E58 CRC64;
MATRRVGRSW EVSPTERRPP AGLRGPAAED AAASPPVLSL SHFCRSPFLC FGDVRLGASR
TLPLVLDNPN DEVAEVKISH FPAPEQGFSV SQRWFELQPK EKIVISVKWT PLKEGRVREI
VTFLVNDVLK HQAILLGNAE EQKKKKRSLW DTSNKKKMSA SSSNKRISCI QNVNKTFCVS
QNVDRVRNPL QACENLAMNE GCSPAENSSL ILEENKIPIS PISPIFKECH GETSLPLSVR
RSTTYTSLHA CENGELLKVE GASILEDFNF SEKVVNETSF NSTNNINGQT EENSKLILTP
NCSSTLSITQ SQGNFLSPDS FVNNSRAANN ELEVVACLSS DTSMKDNSRH VHWESKTVHE
NYQTILSPDS FINDNYGLNQ DLESESINPI LSPNQFVKDN MAYICISQQT CKLSPSSNKN
SQFSQSPQDQ RTNGVLPHIP ECQRSESPKA IFEEPKALEM KSNCYSSTKN RPKFSAVQDI
SSYSHDKLKR RPILSATVTK SKPTCTRENQ KETNKPKAKR CLNSVAGKFE KVTDNQKEKD
DFQSCLPIID PVCNKSTSYK NVITPPSKTT LVARKRKSEG DRDEANVRIT VTEHTEVQEI
KRIHFSPVES KTSTVKKTKK LVIPISKHMN REKLNLKKKT DSLVYRTANS KTNKRTKAIV
AVAHSTLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGVESQHKI SVLRAPTKDE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET IFGELLSLED
NSDVMGLALF ILNRLLWNPD IAAEYRHPTV PHLYRDGHEE ALSKFTLKKL LLLVCFLDYA
KISKLIDHDP CLFCKDAEFK TSKDILLAFS RDFLSGEGDL SRHLSLLGLP VNHVQTPFDE
FDFAVTNLAV DLQCGVRLVR IMELLTRDWN LSKKLRIPAI SRLQKMHNVD IVLQILRSQG
IQLNDEHGNT ILSKDIVDRH REKTLALLWK IAFAFQVDIS LNLYQLKEEI DFLKHTQSMK
KTMSARSCHS DAIINKKKDE RNSGSFEQYS ESIKLLMEWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPYYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDGSSL DLSLRAFDHE
NTSELYKELL ENEKKNFQLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLCKEARAA RLIQTTWRKY KLKTDLKCQQ ERDKAARIIQ SAIITFLTKQ RLKKEINATL
TIQKYWRRLL AQRKLLMLKK EKLEKVQNES ALVIQRYWRR YSTRKQFLKL KYYSIILQSK
IRMIIAVTSY KRHLWAAVTI QRHWCAYLRR KHDQQRYKML KSSCLIIQSM FRRWKQRKMQ
LQIKATVILQ RAFREWHGRK RAKEEKSALV IQSWYRMHQE LRKYIHIRSC VIIIQTRFRC
LQAQKLYKRK KEALLTIQKY YKAYLKGKTE RTSYLQKRAA AIRLQAAFRR MRARNLHRQT
RAACVFQSYW RMRQDRFRFL NLKKITTKLQ AQVRKQQQLQ KYKKVKRAAL VIQIHFRAYV
LAKKVLASYQ KTRSAVIVLQ SAYRGMQARK KFIHILTSII KIQSCYRAYI SRKKFLRLKS
ATVKLQSIVR MKQTHKQYLH LRAATLCIQR QYRSTKMAAL ERQEYRQMRE SCIKLQASVR
GHLVRKQMRV QRQAAVSLQS YFRMRKTRQY YLEIYKATVV IQNYYHAYKA QISQRKNFLQ
VKRAVTCLQA AYRGYKVRQL IKQQSIAALK IQTAFRGYSK RKKYQYMLQS TIKIQRWYRT
YRTVHGVRTQ FLKTKAAVIS LQSAYRGWKV RKQIKREHQA AVRIQSAFRM AKARKQFRLL
KTATLVIQRY LRAWTAGKKQ RMEYIALRKA ALTLQSAWKG KTVRRRIQKQ QARAVIIQSY
YRMYVQQKTW EIMKKAACLI QMYYRAYSVG RKQRQLYLKT RAATVILQSA YRSMRVRKKI
KECNKAAVTI QSTYRAYKTK KNYATCRASA VIIQRWYRGI KIASHQRKDY LNFKKTAVKI
QAIYRGIRVR RQIQHMHMAA TVIQAVFKMH QAKMRYHKMR TAAVIIQVRY RAYCQGKIQH
AKYLTILKAI TVLQASFRGI RVRQTLRKMQ SAATLIQSYY RRHREQTYFS KLKKVTKTVQ
QKYRAVKERN LQFQKYNQLR HSVIRIQAGF RGMKARQHLK IMHLAATLIQ RRFRTLRVRR
RFLSLRKTVL WVQRKYRATV CAKHYFQQFL QLQKAIIKIQ SSYRGWMVRK KMQEMHRAAT
VIQAAFRMHR AYVRYQALKH ASVIIQQQYR ANRAAELQRQ CYLRQRHSAL ILQAAFRGMK
ARGHLKNMHS SATLIQSRFR SLVMRKRFTS LKKAAIFVQR KYRATICAKH HLHQFLKLQK
AVITIQSSYR RLVAKKKLQE MHRAAVLIQA TYRMHRTYVT FQTWKHASVL IQQHYRTYRA
AKLQRENYVR QRHSALVIQA AYKGMKARQL LREKHRAAII IQSTYKMYRQ YLFYQKIQWA
TKVIQKRYRA NKKKVLQHDT LRKAATCIQA DFPDLIIRKQ IQEQHQAATI IQKHFKASKI
RKRYLHLRAK VVFVQRRYRA LIAAHTQAVI CLQSPYRGFE VRKDIQHMHL AATLIQSVYR
MHRAKLDYQA KKTAVVVIQN YYRSYVRVKM ERKRLLAVQK SVLIIQAAFR GMKVRQTLRH
LSEANMAAMA QQSAFCPHRM ETPHGAVHSS ELRVQKWHRA SLMACSQEAE YPQREAAVTT
QKAFCEMVTR KLETQMCAAL RIQSFLQMAV YRRRFVQQKR AAVTLQQYFR TWQTRRQFLL
YRKAAVVLQN HHRAFLSAQH QRQVYLQIRS SIIIIQARTR GFIQKRKFHK IKDSTIKIQA
VWRSYKARKY LHKVKAACKI QAWYRYWKAR KEYLRVLKAV KIIQGCFYTK QERARFLNVR
ASTIIIQRKW RATLAGRIAR EHFLMMKRHR AACLIQANFR RYKGRQVFLR QKSAALTIQR
YIRARKDGKC ERIKYVELKK STVVLQALVR GWLVRKRILE QKTRIRLLHF TAAAYYHLSA
LRIQRAYKLH MALKNANKQV NSVICIQRWF RTKLQQKRFA QKYHSIIKSQ HEIQECMSQQ
NRAASVIQKA VRHFLLCKKQ EKFNNGISKI QALWRGYSWR KKNDCTKIKA IRLSLQLVNR
EIREENKLYK RTALALHYLL TYKHLSAILE ALKHLEVVTR LSPLCCENMA QSGAVSKIFV
LIRSCNRSVP CMEVIRYAVQ VLLNVAKYEK TTAAVYDVEN CIDTLLDLLQ MYREKPGDKV
ADKGGSIFTK ACCLLAILLK TTNRASDVRS RSKVVDRIYS LYKLTARKHK MNTERILYKQ
KMNSSISIPF IPETPVRTRI VSRLKPDWVL RRDKMEEITN PLQAIQMVMD TLGIPY
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